Results 161 to 170 of about 355,304 (389)

AZD0449, an inhaled JAK1 inhibitor, in healthy participants and patients with mild asthma

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Inhaled corticosteroids (ICS) plus bronchodilator are recommended for the treatment of asthma. Targeting the JAK1‐dependent pathway may be an alternative for asthma management in patients with incomplete response to ICS. The aim of this study was to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD0449, a
Anna Lundahl   +11 more
wiley   +1 more source

Double Swallow [PDF]

open access: yesEar, Nose & Throat Journal, 2006
Gregory N, Postma   +2 more
openaire   +2 more sources

Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ9‐tetrahydrocannabinol in older patients with poor appetite

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Cannabis‐based medicines are gaining interest and being explored for new therapeutic indications, many of which commonly affect older medical patients. As most previous studies of the population pharmacokinetics of cannabinoids have been performed in healthy adults, this study aimed to investigate the population pharmacokinetics of Δ9 ...
Ida Klitzing Storgaard   +12 more
wiley   +1 more source

Swallowing Is Differentially Influenced by Retronasal Compared with Orthonasal Stimulation in Combination with Gustatory Stimuli [PDF]

open access: yes, 2017
Identical stimuli are processed differently when presented ortho- or retronasally. In contrast to orthonasal olfaction, retronasal odorant perception is strongly associated with flavor and food intake, which is usually followed by swallowing.
Ebnöther, Myriam   +3 more
core  

Development of a Physiologically Based Pharmacokinetic (PBPK) Simulation Model for Nicotine

open access: yesBiopharmaceutics &Drug Disposition, EarlyView.
This study developed a region‐specific PBPK model for nicotine integrating various administration routes and lung compartments, validated using clinical PK data. This model enables an accurate prediction of nicotine kinetics and supports dose optimization for safer nicotine delivery systems. ABSTRACT Tobacco is a major cause of chronic diseases such as
Brian Kim   +8 more
wiley   +1 more source

Tracheocutaneous fistula in patients undergoing supracricoid partial laryngectomy: the role of chronic aspiration [PDF]

open access: yes, 2015
The aim of the present retrospective controlled study was to analyse and compare risk factors for tracheocutaneous fistula in patients who received tracheostomy after supracricoid partial laryngectomy with those who received tracheostomy for other causes.
Calcagno, P   +8 more
core  

3D bioprinting in oral and craniomaxillofacial tissue regeneration: Progress, challenges, and future directions

open access: yesBMEMat, EarlyView.
This paper summarized the application of 3D bioprinting in the regeneration of various tissues in the oral and craniomaxillofacial fields, including the required biomaterials and printing techniques. Abstract Oral and craniomaxillofacial tissues are essential for maintaining oral functions, including respiration, mastication, swallowing, and speech ...
Huilu Zhan   +7 more
wiley   +1 more source

Shades of Green Labeling: A Bibliometric Analysis

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Sustainability labels are a signal of firms' commitment to environmental, social, and governance (ESG) related goals and can be driven by firms' ESG strategy. There is a multitude of labeling schemes leading to calls for either a simplified, overarching sustainability label or greater harmonization across the existing labels.
Roopali Bhatnagar   +3 more
wiley   +1 more source

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