Results 81 to 90 of about 285,833 (292)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The energy content and demographic composition of Antarctic krill (Euphausia superba) swarms in East Antarctica

Frontiers in Marine Science
Antarctic krill (Euphausia superba) aggregations are important in the Southern Ocean ecosystem; however, the amount of energy that krill swarms contain is unknown. We assessed the population structure of E.
Camila Cataldo-Mendez, Camila Cataldo-Mendez, So Kawaguchi, So Kawaguchi, Martin J. Cox, Martin J. Cox, Martin J. Cox, Jessica Melvin, Victor Rae, Kerrie M. Swadling, Kerrie M. Swadling   +10 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Gaslike Social Motility: Optimization Algorithm with Application in Image Thresholding Segmentation

Algorithms
This work introduces a novel and practical metaheuristic algorithm, the Gaslike Social Motility (GSM) algorithm, designed for optimization and image thresholding segmentation.
Oscar D. Sanchez, Luz M. Reyes, Arturo Valdivia-González, Alma Y. Alanis, Eduardo Rangel-Heras   +4 more
doaj   +1 more source

Reconfigurable magnetic microrobot swarm: Multimode transformation, locomotion, and manipulation

Science Robotics, 2019
Magnetic microrobot swarms collectively perform tasks in a confined environment through multimode transformation and locomotion. Swimming microrobots that are energized by external magnetic fields exhibit a variety of intriguing collective behaviors ...
Hui Xie, Mengmeng Sun, Xinjian Fan, Zhihua Lin, Weinan Chen, Lei Wang, Lixin Dong, Q. He   +7 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Design of Control Strategy for Swarm Autonomous Vessels for Circling Mission in Calm Water

International Journal of Coastal and Offshore Engineering, 2016
Control of a group of autonomous surface vessels, called agents, with realistic dynamic for circling mission is addressed with the aid of Lyaponov and graph theory.
Hassan Sayyaadi, Abbas Ghasemzade Ahrami
doaj  

Robust Optimization Models for Planning Drone Swarm Missions

Drones
This article presents methods of planning unmanned aerial vehicle (UAV) missions in which individual platforms work together during the reconnaissance of objects located within a terrain.
Robert Panowicz, Wojciech Stecz
doaj   +1 more source