Results 61 to 70 of about 208,077 (237)

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Two cases of sweat gland carcinoma with neurosecretory differentiation: A report

Indian Journal of Pathology and Microbiology
Hidradenocarcinoma (HC) is an extremely rare malignant tumor originating from skin appendages, accounting for approximately 6% of malignant sweat gland tumors and less than 0.001% of all tumors.
Ting Xu, Rui Zou, Xue Meng, Shunfu Yu
doaj   +1 more source

Data‐Driven Design of Self‐Adhesive Epidermal Electrodes and Sensors

Advanced Science, EarlyView.
This work presents self‐adhesive, stretchable epidermal electrodes and sensors developed through a data‐driven design framework that integrates artificial neural networks with genetic algorithms. By tailoring optimization objectives, either maximizing electrical conductivity and adhesion or enhancing piezoresistive sensitivity, the study enables the ...
Xuan Li, Shilei Wang, Milad Razbin, Danish Tahir, Chen Sang, Shuhua Peng, Markus Müllner, Wenlong Cheng, Wei Chen, Chun Hui Wang, Shuying Wu   +10 more
wiley   +1 more source

Multipotent nestin-positive stem cells reside in the stroma of human eccrine and apocrine sweat glands and can be propagated robustly in vitro. [PDF]

PLoS ONE, 2013
Human skin harbours multiple different stem cell populations. In contrast to the relatively well-characterized niches of epidermal and hair follicle stem cells, the localization and niches of stem cells in other human skin compartments are as yet ...
Sabine Nagel, Franziska Rohr, Caroline Weber, Janina Kier, Frank Siemers, Charli Kruse, Sandra Danner, Matthias Brandenburger, Anna Emilia Matthiessen   +8 more
doaj   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Bio-sensing textile based patch with integrated optical detection system for sweat monitoring [PDF]

, 2009
Sensors, which can be integrated into clothing and used to measure biochemical changes in body fluids, such as sweat, constitute a major advancement in the area of wearable sensors.
Wallace, Gordon, Morris, Deirdre, Coyle, Shirley, Wu, Yanzhe, Lau, King-Tong, Diamond, Dermot   +5 more
core   +2 more sources

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

Wilson protein expression, copper excretion and sweat production in sweat glands of Wilson disease patients and controls

BMC Gastroenterology, 2008
Background In Wilson disease, copper is not sufficiently excreted into bile due to the absence or malfunction of the Wilson protein copper ATPase in the excretory pathway of hepatocytes. Copper is found in sweat. It is unknown if the Wilson protein plays
Weiss Karl, Merle Uta, Schellenberg Mavi, Schaefer Mark, Stremmel Wolfgang   +4 more
doaj   +1 more source

Isolation strategy for sweat gland LRCs.

, 2013
(A) Whole K5TetOff/TreH2BGFP toe tip under the stereomicroscope, dotted yellow line marks sweat gland dissection. (B) Dissected sweat glands with surrounding sole’s epidermis.
Eve Kandyba (460406), Yvonne Leung (460405), Seth Ruffins (356510), Krzysztof Kobielak (460407), Yi-Bu Chen (66776)   +4 more
core   +1 more source