Results 91 to 100 of about 548,390 (342)

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy

open access: yesAdvanced Science, EarlyView.
This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang   +12 more
wiley   +1 more source

Idiopathic generalized anhidrosis with absence of sweat glands: A case report and literature review

open access: yesDermatologica Sinica, 2018
Idiopathic generalized anhidrosis is a rare disease characterized by sweating impairment despite exposure to heat or exercise. It could be congenital or acquired. We reported a 22-year-old male with generalized anhidrosis, except axillae, forehead, palms
Chih-Ting Chen, Ding-Dar Lee
doaj  

An MOF‐Enhanced Anti‐Fouling Immunoprobe Platform for Efficient Direct Screening of Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This work introduces an electrochemical sensing method that employs an innovative platform based on metal‐organic framework (MOF) for detecting biomarkers. The platform integrates an antifouling surface, oriented antibody immobilization, and an enhanced electron transfer layer.
Wenjuan Yang   +10 more
wiley   +1 more source

Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro.

open access: yesJournal of Clinical Investigation, 1984
Abnormal ductal NaCl absorption has been known as the only defect in cystic fibrosis (CF) sweat glands. We have fortuitously found that the secretory portion of CF sweat glands is also abnormal in that it failed to show a sweating response to beta ...
K. Sato, F. Sato
semanticscholar   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

open access: yesAdvanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang   +21 more
wiley   +1 more source

Measurement of thermal sweating at rest and steady-state exercise in healthy adults: Inter-day reliability and relationships with components of partitional calorimetry

open access: yesPLoS ONE, 2022
Objective Inter-day reliability of sweat measurements, including the absorbent patch and modified iodine-paper techniques, at rest and exercise were evaluated.
Jennifer S. Peel   +5 more
doaj  

Sympathetic innervation of the sweat glands and piloarrector muscles of macaques and human beings.

open access: yesJournal of Investigative Dermatology, 1977
A loose network of catecholamine-containing nerve terminals (adrenergic nerves) has been demonstrated around some of the coils of human and macaque ecerine sweat glands with the histofluorescence method [1–4]. After administration of the monamine oxidase
H. Uno
semanticscholar   +1 more source

Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
The aberrant adenosine metabolism leads to chemoresistance and immunosuppressive microenvironment. A versatile albumin‐polyplexes conjugated nanoparticle B‐PDEA@CPA is prepare for the codelivery of gemcitabine and siCD39. The nanoparticle releases gemcitabine‐loaded albumin upon microenvironment to achieve promoted penetration and cellular uptake ...
Hongrui Fan   +10 more
wiley   +1 more source

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