Results 31 to 40 of about 285,460 (266)

What made Proto-Germanic *jah ‘and’ an infinitive marker in westernmost Uralic? Observations from the Saami-Scandinavian border

open access: yesNorsk Lingvistisk Tidsskrift, 2017
The paper provides an account of a previously neglected infinitive marker in South Saami. Originally recognized by Bergsland (1946), later descriptions of South Saami have disregarded the use of the coordinating conjunction jih ‘and’ as what appears to ...
Jussi Ylikoski
doaj  

Creating a Historical Migration Dataset from Finnish Church Records, 1800–1920

open access: yesJournal of Open Humanities Data
This article presents a large-scale effort to create a structured dataset of internal migration in Finland between 1800 and 1920 using digitized church moving records.
Ari Vesalainen   +6 more
doaj   +1 more source

Does surgeon experience affect patient-reported outcomes 1 year after primary total hip arthroplasty?: A register-based study of 6,713 cases in western Sweden

open access: yesActa Orthopaedica, 2018
Background and purpose — Several studies have reported on the influence of various factors on patient-reported outcomes (PROs) after total hip arthroplasty (THA), but very few have focused on the experience of the surgeon. We investigated any association
Per Jolbäck   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

How to develop historical consciousness through uses of history – A Swedish perspective

open access: yesHistorical Encounters: A Journal of Historical Consciousness, Historical Cultures, and History Education, 2020
Historical consciousness is the central concept in Swedish history education and the aim of history teaching in Swedish schools is to develop students’ historical consciousness. In 2015 the Swedish Schools Inspectorate, a government body responsible
Robert Thorp
doaj   +1 more source

Bicycling during alcohol intoxication

open access: yesTraffic Safety Research, 2023
The number of bicycling fatalities was 19 450 between 2010 and 2018 in Europe. The number of bicyclists killed when intoxicated by alcohol is harder to establish given the lack of reliable data.
Jan Andersson   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Improved Prediction of Forest Variables Using Data Assimilation of Interferometric Synthetic Aperture Radar Data

open access: yesCanadian Journal of Remote Sensing, 2017
The statistical framework of data assimilation provides methods for utilizing new data for obtaining up-to-date forest data: existing forest data are forecasted and combined with each new remote sensing data set.
Nils Lindgren   +9 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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