Results 141 to 150 of about 10,169 (345)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Studies on Synthetic Sweetening Agents. I
, 1962 Hisashi Ichibagase, Shoji Kojima
openalex +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to sugar-free chewing gum with pyro- and triphosphates and reduction of calculus formation (ID 1309) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [PDF]
, 2011 Edgar +6 more
core +1 more source
An Empirical Study on Gur (Jaggery) Industry (with special reference to operational efficiency & profitability measurement) [PDF]
Gur (Jaggery) is a natural, traditional product of sugarcane. It can define as a honey brown coloured raw lump of sugar. Kushinagar district of Uttar-Pradesh has large number of Gur manufacturing units, mostly located in the rural areas and the ...
Dwivedi Amit Kumar
core
Studies on Synthetic Sweetening Agents. VI. Absorption and Excretion of Sodium Cyclamate.(1)
, 1966 Shoji Kojima +2 more
openalex +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Studies on Synthetic Sweetening Agents. XI. : Colorimetric Determination of Dulcin. (2)
, 1967 Hisashi Ichibagase +2 more
openalex +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source