Results 31 to 40 of about 152,823 (267)

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Swimming with the fishes [PDF]

BMJ Case Reports, 2014
We describe the case of a healthy 23-year-old man who presented to the emergency room with a 10 h history of sharp left lower chest pain occasionally radiating to the epigastrium. The pain had started acutely while he was eating dinner at a restaurant in New York City and he noticed it during swallowing.
Tokunbo, Ajayi, Khoa, Do, Ashmeet, Bhatia, Avenir, Mulita   +3 more
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Evaluating the swimming technique analysis: a multi-criteria decision approach using hesitant bipolar fuzzy with a GRA approach

Scientific Reports
Modern technology has played a significant role in improving the analysis and training of swimming, providing more accurate results. Also, finding the best swimming technique is still complicated because there are conflicting standards and uncertainty ...
Qing Li, Jianxia Yin
doaj   +1 more source

The Least Squares Method as a Tool for Assessment of the Stroke Parameters and Velocity in Monofin Swimming

Methods and Protocols
This study explores the application of the Least Squares Method to analyze and model the kinematic parameters in monofin swimming, focusing on stroke rate, stroke length, and the amplitudes of joint displacements at the hip, knee, and ankle.
Marek Rejman, Paweł Szkudlarek
doaj   +1 more source

Correlations between linear sprint with the ball, linear sprint without the ball, and change-of-direction without the ball in professional female soccer players

Scientific Reports, 2023
The evolution of female soccer is related to the increase in high-intensity actions and choosing the abilities that best characterize the players' performance. Determining the capabilities that best describe the players' performance becomes essential for
Artur Avelino Birk Preissler, Pedro Schons, Filipe Manuel Clemente, Guilherme Droescher de Vargas, Lucas Moraes Klein, Ana Filipa Silva, Hadi Nobari, Luiz Fernando Martins Kruel   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Quantity of within-sport distance variety – what can pool swimmers and track runners learn from each other?

Frontiers in Sports and Active Living
ObjectiveTo determine the relationship between success at peak performance age and quantity of within-sport distance variety and compare the dose-time-effect between swimming and track running by determining probability of becoming an international-class
Dennis-Peter Born, Dennis-Peter Born, Dennis-Peter Born, Jenny Lorentzen, Glenn Björklund, Jesús J. Ruiz-Navarro   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells

Toxics, 2021
Due to their beneficial properties, the use of zinc oxide nanoparticles (ZnO NP) is constantly increasing, especially in consumer-related areas, such as food packaging and food additives, which is leading to an increased oral uptake of ZnO NP ...
Anna Mittag, Christian Hoera, Alexander Kämpfe, Martin Westermann, Jochen Kuckelkorn, Thomas Schneider, Michael Glei   +6 more
doaj   +1 more source