Results 181 to 190 of about 455,182 (244)
Advanced Science, EarlyView.In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang +6 more
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Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
Advanced Science, EarlyView.A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati +10 more
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Advanced Science, EarlyView.CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen +19 more
wiley +1 more source
Object Lessons is a series of short, beautifully designed books about the hidden lives of ordinary things. The story of swimming has no beginning or end. Ever since humans glimpsed the open sea, or a pond, or a river, they have strived to reach the other shore. A swimming pool puts that goal within our reach, if only metaphorically.
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American Physical Education Review, 1912
The care of swimming-pools in educational institutions and athletic clubs has of late years attracted considerable attention. Notable studies have been made, among which may be especially mentioned those at Brown University, and by Dr. William J. Lyster at the University of Pennsylvania.
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The care of swimming-pools in educational institutions and athletic clubs has of late years attracted considerable attention. Notable studies have been made, among which may be especially mentioned those at Brown University, and by Dr. William J. Lyster at the University of Pennsylvania.
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2018 11th International Conference on IT Security Incident Management & IT Forensics (IMF), 2018
In the world of cryptocurrency-related malware, mining Monero (XMR) is a growing threat for organizations. In this paper we will explain why Monero is appealing for malicious actors, and how to leverage publicly available sources for hunting of Monero-related activities.
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In the world of cryptocurrency-related malware, mining Monero (XMR) is a growing threat for organizations. In this paper we will explain why Monero is appealing for malicious actors, and how to leverage publicly available sources for hunting of Monero-related activities.
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Hastings Center Report, 2007
My job was simple: Write an essay reviewing four exciting books--two on the general topic of health care justice, and two on health care policy. 1,103 pages of scholarly discourse, and what did I find myself thinking about? Swimming pools, of course. I take care of patients within the Veterans' Administration system. Most of them have limited financial
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My job was simple: Write an essay reviewing four exciting books--two on the general topic of health care justice, and two on health care policy. 1,103 pages of scholarly discourse, and what did I find myself thinking about? Swimming pools, of course. I take care of patients within the Veterans' Administration system. Most of them have limited financial
openaire +2 more sources
American Physical Education Review, 1908
(1908). The Swimming Pool. American Physical Education Review: Vol. 13, No. 4, pp. 228-232.
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(1908). The Swimming Pool. American Physical Education Review: Vol. 13, No. 4, pp. 228-232.
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American Physical Education Review, 1920
(1920). The Swimming Pool. American Physical Education Review: Vol. 25, No. 9, pp. 383-399.
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(1920). The Swimming Pool. American Physical Education Review: Vol. 25, No. 9, pp. 383-399.
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