Results 41 to 50 of about 34,632 (181)

Novel reassortant of H1N1 swine influenza virus detected in pig population in Russia

Emerging Microbes and Infections, 2019
Pigs play an important role in interspecies transmission of the influenza virus, particularly as “mixing vessels” for reassortment. Two influenza A/H1N1 virus strains, A/swine/Siberia/1sw/2016 and A/swine/Siberia/4sw/2017, were isolated during a ...
Ivan Sobolev, Olga Kurskaya, Sergey Leonov, Marsel Kabilov, Tatyana Alikina, Alexander Alekseev, Yuriy Yushkov, Takehiko Saito, Yuko Uchida, Junki Mine, Alexander Shestopalov, Kirill Sharshov   +11 more
doaj   +1 more source

TRANSMISSION OF SWINE INFLUENZA VIRUS BY LUNGWORM MIGRATION [PDF]

The Journal of Experimental Medicine, 1961
Experimental evidence is presented which confirms the reports by Shope (1, 2) that swine lungworms can serve as an intermediate host in transmitting swine influenza virus to pigs. The virus is present in a masked non-infective form as he showed and a provocative stimulus is necessary to initiate infection.
Sen, H.G., Kelley, G.W., Underahl, N.R., Young, G.A.   +3 more
openaire   +2 more sources

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Epidemic Status of Swine Influenza Virus in China [PDF]

Indian Journal of Microbiology, 2013
As one of the most significant swine diseases, in recent years, swine influenza (SI) has had an immense impact on public health and has raised extensive public concerns in China. Swine are predisposed to both avian and human influenza virus infections, between that and/or swine influenza viruses, genetic reassortment could occur.
Weili, Kong, Jiahui, Ye, Shangsong, Guan, Jinhua, Liu, Juan, Pu   +4 more
openaire   +2 more sources

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Origin and Evolution of H1N1/pdm2009: A Codon Usage Perspective

Frontiers in Microbiology, 2020
The H1N1/pdm2009 virus is a new triple-reassortant virus. While Eurasian avian-like and triple-reassortant swine influenza viruses are the direct ancestors of H1N1/pdm2009, the classic swine influenza virus facilitate the spectrum of influenza A ...
Fucheng Guo, Jinjin Yang, Junbin Pan, Xianghui Liang, Xuejuan Shen, Xuejuan Shen, David M. Irwin, David M. Irwin, Rui-Ai Chen, Rui-Ai Chen, Yongyi Shen, Yongyi Shen   +11 more
doaj   +1 more source

Genetic characterization and pathogenicity of a Eurasian avian-like H1N1 swine influenza reassortant virus

Virology Journal, 2022
Background Swine influenza viruses (SIV), considered the “mixing vessels” of influenza viruses, posed a significant threat to global health systems and are dangerous pathogens.
Hechao Zhu, Xiangmin Li, Huanchun Chen, Ping Qian   +3 more
doaj   +1 more source

Swine as a Model for Influenza A Virus Infection and Immunity [PDF]

ILAR Journal, 2015
Influenza A viruses (IAVs) infect a variety of hosts, including humans, swine, and various avian species. The annual influenza disease burden in the human population remains significant even with current vaccine usage, and much about the pathogenesis and transmission of influenza viruses in humans remains unclear.
Daniela S, Rajao, Amy L, Vincent
openaire   +2 more sources

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source