Results 31 to 40 of about 4,532 (269)
Production of metal powders by gas atomization using swirl and non-swirl nozzles
Nihon Kikai Gakkai ronbunshu, 2022 Gas atomization, in which high-pressure gas jet impinges on molten metal stream from the melt tube to atomize it, is a popular method of producing fine metal powders. In this study, we focused on a swirling flow of the injection gas as a factor affecting
Kazuki YOSHIMURA, Kazuya SAITO
doaj +1 more source
Bubble elimination by swirl flow.
Hydraulics & Pneumatics, 1988 The performance of a newly developed bubble elimination system is analyzed. The system consists of a circular body for a swirled flow supplied tangentially, equiped with a throttle valve downward and a valve for discharging bubbles upward.A strong swirl superimposed on an averaged laminar flow during the initial state is found to decay exponentially ...
SUZUKI, Ryushi +2 more
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Advances in Unsteady Dynamics of Secondary Flow in 90° Pipe Bends [PDF]
长江科学院院报[Objective] The unsteady motion of secondary flow, namely Dean vortices, in bent pipes can induce thermal fatigue and mechanical fatigue, posing a serious threat to the safe operation of industrial piping systems.
WANG Zhi-xin, HAN Song-lin, JIANG Zhi-bing
doaj +1 more source
Numerical Simulation and Experimental Study on Flow Field in a Swirl Nozzle
Shock and Vibration, 2021 In order to study the internal flow characteristics and external droplet velocity distribution characteristics of the swirl nozzle, the following methods were used: numerical simulations were used to study the internal flow characteristics of a swirl ...
Yicheng Sun +4 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source