Results 41 to 50 of about 53,364 (314)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Numerical Simulation and Experimental Study on Flow Field in a Swirl Nozzle
Shock and Vibration, 2021 In order to study the internal flow characteristics and external droplet velocity distribution characteristics of the swirl nozzle, the following methods were used: numerical simulations were used to study the internal flow characteristics of a swirl ...
Yicheng Sun +4 more
doaj +1 more source
Characterisation of barrel swirl motion under steady flow conditions [PDF]
, 1995 The purpose of this paper is to characterise the flow field through the inlet valves, and tumble to swirl conversion tube of a steady state flow rig using HWA. LDA and CFD techniques.
Baker, P. +4 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Advances in Unsteady Dynamics of Secondary Flow in 90° Pipe Bends [PDF]
长江科学院院报[Objective] The unsteady motion of secondary flow, namely Dean vortices, in bent pipes can induce thermal fatigue and mechanical fatigue, posing a serious threat to the safe operation of industrial piping systems.
WANG Zhi-xin, HAN Song-lin, JIANG Zhi-bing
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Mesh Twisting Technique for Swirl Induced Laminar Flow Used to Determine a Desired Blade Shape
Applied Sciences, 2018 Swirling flow has been shown to increase heat transfer in heat exchangers. However, producing swirl while not presenting a severe pressure drop can be a challenge.
Ásdís Helgadóttir +3 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Swirl flow response to transverse and axial acoustic forcing
Journal of Fluid Science and Technology, 2014 The present study is an experimental investigation on the effect of axial and transverse acoustic forcing on a generic swirl flow. The aim is to provide a qualitative understanding of typical swirl flow response to transverse acoustic forcing, for a ...
Aditya SAURABH +1 more
doaj +1 more source