Results 101 to 110 of about 1,943,775 (315)
THE STRESS-STRAIN STATE OF THE SWITCH TYPE R65 MARK 1/11 PROJECT DN 300
Nauka ta progres transportu, 2010 The results of full-scale strength test of the switch type R65 mark 1/11 of the design Dn 300 are described.
K. V. Moyseyenko, V. P. Gnatenko
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Nauka ta progres transportu, 2011 The results of experimental research of influence of length of a direct insert between adjacent switches laid according to the first scheme on admissible speeds of movement of trains by criterion of switch strength and the strained-and-stressed state of ...
K. V. Moyseyenko
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Práctica de aplicación de seguridad y distribución de LAN corporativa
Universidad y Sociedad, 2018 La alta demanda de en una red empresarial al área de TI nos incita a la incesante búsqueda de nuevas técnicas para precautelar y proteger la información generada por una empresa.
Jorge Humberto Tapia Celi +2 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
Journal of Clinical Investigation, 2007 C. Lumeng, Jennifer L Bodzin, A. Saltiel
semanticscholar +1 more source