Results 171 to 180 of about 113,082 (256)

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

Vascular adventitial cells and vascular remodeling: when a harp of thousand strings does not keep in tune so long. [PDF]

Front Physiol
Sebastian M, Vijayakumar A, Jayachandran P, Wang M, Kailasam S.   +4 more
europepmc   +1 more source

Programmable Microgel Degradation in Dynamic Granular Hydrogels Guides Extracellular Matrix Assembly During Tissue Repair

Advanced Materials, EarlyView.
This study reports on the chemical modification of hyaluronic acid to create hydrogels with hydrolytic degradability ranging from 2–28 days. Granular hydrogels that undergo timed degradation to increase porosity enhance cell invasion and provisional ECM remodeling in a muscle injury model, leading to reduced fibrosis and improved regeneration ...
Zhiyuan Chen, Tuba Marjan, Xinyue Lu, Nicole E. Mertens, Keira Vesy, Dean E. Stornello, James F. Markworth, Taimoor H. Qazi   +7 more
wiley   +1 more source

<i>GJA1</i> dysfunction suppresses Wnt/c-MYC signaling and promotes inflammatory imbalance and MMP3-associated ECM remodeling in fibroblasts and mesenchymal stromal cells from patients with ODDD. [PDF]

Front Cell Dev Biol
Tao S, Zhao B, Wang X, Shen X, Zhao X.
europepmc   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Cadherin-11 and the mechanobiology of the fibrogenic niche. [PDF]

Kidney Int
Jiang S, Suleiman HY, Genin GM.
europepmc   +1 more source

Ferroionic‐Assisted, Charge‐Driven Polymorphic Phase Engineering for Multilevel Memristive Devices

Advanced Materials, EarlyView.
A CuInP2S6/Mo0.92W0.08Te2 heterostructure enables a gradual semiconductor‐to‐semimetal phase transition through Cu+ ion migration and charge accumulation. The spatially engineered 2H/1T′ mixed phases produce continuously tunable conductance states in a two‐terminal geometry, while suppressing depolarizing fields and stabilizing the metastable 1T′ phase.
Nayeon Kim, Chengqi Wei, Eunji Hwang, Woohyun Cho, Heemyoung Hong, Yongjoon Lee, Daeho Noh, Min Seok Jang, Zhongrui Wang, Heejun Yang   +9 more
wiley   +1 more source

Vascular Smooth Muscle Cell Plasticity in Atherosclerosis: Mechanisms, Recent Advances, and Therapeutic Implications. [PDF]

Rev Cardiovasc Med
Li T, Niu X, Lu L, Liang Y, Zhang L.
europepmc   +1 more source

A Family of Sodium Solid‐State Electrolytes Based on the NaGaxAl1‐xCl4 Solid Solution

Advanced Materials Interfaces, EarlyView.
ABSTRACT Sodium‐based metal chloride solid electrolytes are promising for sodium solid‐state batteries due to their excellent oxidation stability, which, as shown for Li halides, can coexist with high ionic conductivity. To explore cationic substitution effects, we synthesized NaGaxAl1‐xCl4 (0 ≤ x ≤ 1) via ball milling and investigated structural and ...
Hao Guo, Matteo Bianchini
wiley   +1 more source