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Peri‐operative glucagon‐like peptide‐1 receptor agonist use and outcomes: a national prospective multicentre cohort study
Anaesthesia, EarlyView.Summary Introduction
Peri‐operative glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) use is associated with delayed gastric emptying. It is unclear what proportion of patients having anaesthetic care are receiving GLP‐1 RAs; what strategies are used in their peri‐operative management; and whether the incidence of pulmonary aspiration and/or ...Thomas E. Potter, John N. Cronin, Justin Kua, Sophie Bloomfield, Mayur Murali, Frances Beatty, Andrew McKechnie, Danny J. N. Wong, Kariem El‐Boghdadly, on behalf of the GLIMPSE Resident Research Networks and Collaborators, Emily Beckett, Jessica Summers, Ellen Gorman, Abigail Brady, Chloe Butel, David Carter, Hei Chan, Rachel Elwood, Alexandra Gosling, Sarah Higgi, Katie MacNaughton, Radharetnasivan Meiarasu, Ellie Morgan, Emily Ratford, Nick Roberts, Sam Smith, Samuel Smith, Abigail Townsend, Helen Williams, Tom Woodhouse, Isabel Griffiths, Mohamed Hussein, Matilda John Ravindran, Joe Joseph, Matthew Sinnott, Sonia Andleeb, Jana Balogova, Sameera Fernando, Elizabeth Hardman, Adedoyin Ilesanmi, Chinmayi Kattimani, Prachi Nisar, Sanjay Sakholiya, Dristi Sharma, Victor Ade‐Davis, Hamza Anwar, James Bigley, Beata Biro, Rhiannon Brignall, Yousef Eltuhamy, Bhavesh Gohil, Anand Krishna, Shilpee Kumari, Jack Lu, Grace Newton‐Livens, Olanrewaju Kazeem, Madeleine Payne, Toby Reynolds, Rosanna Sasson, Henry Somers, Katy Surman, Francois Taljard, Eloise Wilson, Rama Aubeeluck, Reardon Jeffries, Kiran Mehta, Charlotte Moss, Michael Standen, Jebu Thomas, Toska Ukaj, Nidhi Vedd, Judith Wilson, Rachael Allen, Luke Auterson, Anne Bailey, Aideen Casey, Christine Clarke, Michael Crowe, Lauren Crozier, Melissa Flynn, Michael Getty, Ellen Gorman, Fergal Grannell, Laura Gray, Lynsay Greer, Brendan Haughey, Rosemary Hogg, Bhalwel Iqbal, Sagitha Joseph, Ewan Martin, Joanna McAteer, Jennifer McCann, Sarah McCann, Anna McCloy, Rachel McKee, Nicholas McNaughton, Emma McQuillan, Anjum Raheel, Hossam Abdelmotaal, Dominic Barton, Billy Holt, Richard Pugh, Jamie Scriven, Linda Warnock, Adarsh Aji, Maria Hussain, Amelia Kalwajtys, Lydia Meighen, Simon Mills, Sean Wynn, Anna Biggins, Rachael Brennand, Saxon Burnett, Jamie Clarke, Kiran Hassan, Dana Khoshnaw, Emily Langford, Andrew McKendry, Shaminder Kaur Olney, Rhean Rymell, Craig Smith, Rebecca Walford, Adam Windle, Benjamin Booker, Annabelle Crouch, Claudia Esquirol, James Hollamby, Danielle Huckle, Thomas Loka, Dominic Manetta‐Jones, Deborah Mann, Amy Matthews, Thomas Parry, James Perring, Ishani Sinha, Oliver Thomas, Molly Timlin, Thomas Wand, Zach Wardle, Lauren Warrington, Rosie Watts, Megan Williams, Sylwia Bartoszewicz, Khristianne Greenhalgh, Hannah Greensmith, Judy Havinga, Tanya Jayawardena, Josh Wall, Sophie Wouters, Katherine Woods, Sundar Ashok, Eleanor Cartwright, Amie Desancha, Genevieve Lawrence, Michael Masucci, Mitul Patel, Shirley Zhang, Katharine Barr, Mark Futcher, Christine Garner, Mehtaab Johal, Bradley Postill, Hannah Atkins, Nick Hooper, James Lumb, Molly Mercurio, Charlotte O'Driscoll, Nick Riddler, Sally Roscoe, Deepa Sannakki, Kamal Sayes, Jie Tan, James Wheeler, Matt Williams, Hoda AbouGhoneim, Philip Blackie, Lucy Connolly, Hikkaduwe Liyanage Priyangani Dharmapala, Ahmed Hassan, Samuel Hutchinson, Nandhini Joseph, Rito Kapoor, Evelyn Ledwidge, Edward Parkinson, Uma Patel, Niamh Sargeant, Garpagalakshmi Selvamani, Mia Sheikh, William Sloper, Heledd Thomas, Mohammed Akuji, Ayesha Danayal, Jack Doherty, Eleanor Gunn, Thomas Hubberstey, Robyn Mclean, Marrigje Nell, Jack Warbey, Sinan Bahlool, Jessica Bowen, Hugh Dalton, Mark Higgins, Alice Hipsey, Marten Lau, Milind Bhagwat, Gargee Bhatt, Aditya Bidi, Asmaa Hassan, Gianfranco Messina, Ashraf Motawea, Akshita Nagpal, Hima Nambiar, Radhika Patel, Henna Sattar, Yunus Sheikh, Niketa Shukla, Jithu Subhash, Arlin Thomas, Paraskevi Tsiotsi, Saad Zangie, Kate Kendrick, Simran Mann, Fergus Newing, Camilla Pople, Manav‐Vikram Singh, Rebecca Thorne, Owen Duffey, Grace Hillsmith, Matthew Judd, Rachael Lucas, Rebecca Pease, Nicola Powley, David Smith, Benjamin Magnus, Haripriya Rayasam, Jessica Wills, Himali Vitharana, Phoebe Owen, Louise Aaron, Anila Basheer, William Gatfield, Alex Gittens, Hannah Glatzel, Katie Keen, Roland King, Freddie Kirk‐Patrick, Laura Arnott, Joanne Mullender, Gemma Talling, Isobel Thornton, Lucy Williams, Thomas Woodland, Samuel Chequer, Urmila Cockerill, John Cronin, Jedd Da'Costa, Chantelle Gasa, Arhaan Haridas, Sophie Hetherington, Harjot Kaur, Mehakdeep Kaur, Aadya Khatuwala, Chrysostomos Kkamaris, Alexandra Munro, Arjun Nirmal, Nayan Perera, Thomas Potter, Thomas Reed, Suhani Shrestha, Thomas Collyer, Benjamin Huggon, Jack Sherlock, Matthew Smith, Chloe Start, Jasmine Wilkinson, Jack Willis, Steven Worthington, Kerri Clarke, Osayamen Iyekekpolor, Nicholas Moore, Lloyd Brown, Allen George, Rose Lefley, Stephen McAleer, Paul Parker, Joseph Simpkin, Rachel Turner, Gareth James, Aashika Luintel, Adam Ryan, Alun Thomas, Patrick Doyle, Isabelle Ferarrio, Jennifer Illingworth, Sana Iqbal, Somalia Mukherjee, Saaman Neriman, Catherine Onuorah, Anna Preston, Adam Savage, Kathryn Singh, Sanooj Soni, Joel Sugarman, Sophie Tillman, Drew Walker, Harshana Wilgamuwa, Janani Yogeswaran, Zahra Choudhury, Eleanor Dooley, Nosaiba Ezzelarab, Daveena Meeks, Sofia Peacock, Adam Davies, Thomas Hall, Sophia Khaleeq, Rachel Simper, Katie Turley, William Turner, Georgia Vellacott, Meg Barker, Ella Billson, Ian Chadderton, Elinor Clark, 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Michaela Monaghan, Mohammed Rageh, Venkatesh Ramakrishnan, Maya Shah, Omkar Upputuri, James Winstanley, Mike Blundell, Emma Ladlow, Magde Albarade, Rosanna Baker‐Wilding, Marika Blackham, Ajish Cheruvathur, Natalie Edwards, Ahmed Elfaioumy, Tom Fletcher, Shanu George, Zakiya Maryam, Sindhu Sridhar, Dinesh Suryanarayanarao, Ashleigh Wood, Sheena Cheung, Joseph Gallaher, Naomi Lucas, Sophie Ragbourne, Tim Vorster, Mubashar Asif Bhatti, Edward Costar, Stephanie Edmunds, Sim Gill, Zubair Khalif, Duncan Paterson, Harriet Perkins, Elizabeth Ramsay, James Reilly, Ismail Ahmad Shaikh, Sameh Ahmed, Helen Bowes, Oliver Eastwood, Samiha Ismail, Sayali Khandekar, Annabel Ottilie Lloyd‐Thomas, Clare Morkane, Christopher Ng, Alexkumar Patel, Alice Roberts, Rohit Rohit, Sagar Saha, Laura Shepherd, Pooja Singh, Sibthein Khalid, Rotimi Latinwo, Prasan Panagoda, Maya Sussman, Hassan Abdullah, Sarah Clayton, Ahmad Daebis, Christopher Jennings, Nomonde Laxa, William Rea, Wael Zghaibe, Tim Cook, William 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Worrall, Abdel Aziz Younes Ibrahim, Steven Coulson, Richard Fenton, John Hickman, Sarah Jackson, Tom Searle, Aashkaben Shah, Imogen Smith, Olivia Craig‐McFeely, Will Denehan, Abdelrahman ElGamal, Ramy Khalil, Robyn Lee, Hannah Theobald, Jack West, Robert Wiltshire, Amy Yeoman, Jeremy Fabes, Felix Flechtner, Robert Kirby, Rachel Atkinson, Alice Ball, Natalie Bell, Fraser Cohen, Oscar Freund‐Williams, Oliver George, Stephen Grant, Sarah Hodge, Marc Leach‐Tuite, Sarah Leatham, Raphael Levy, Rupert Mason, Charles Orr, Jonas Schlautmann, Nazia Siddiqui, Amrik Virdi, Eleri Clarke, Brett Doleman, Gabrielle Harrison, Michael Jarvis, Sofia Korre, Olivia Lambourne, Jessica Shepherd, Shalini Sriemevan, Fahad Zahid, Sakshi Beotra, Gabrielle Budd, Faiza Buhari, Kodithuwakku A Ramya Dissanayake, Achese Inimgba, Anamika Kansal, Kaushik Makam, Gautam Pati, Meenal Rana, Varu Senanayake, Zahra Siddiqui, Manpreet Singh, Jenq Uei Tan, Vishal Ashokkumar Unadkat, Chamika Wanigasundara, Suhao Yap, Rachael Faulkner, Shehla Shakooh, Tom Woodhouse, Andrew Carmichael, Anna Darling, Ashleigh Gillanders, Simon Smith, Timothy Spence, Joseph Carey‐Jenkins, Zoe Demetriou, Lauren Huyton, Tobias McGregor, Amy Spicer, Ann Biju, Jasper Craib, Ryan Davies, Jenny Edwards, Ross Leigh, Matthew Boyle, Rhys Broughton, Ben Chandler, Georgina Chapman, Eric Chiang, Matthew Eardley, Sumaya Liban, John O'Rourke, Callan Robinson‐Lynch, Murray Williams +862 morewiley +1 more sourceCholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents
British Journal of Pharmacology, EarlyView.Background and Purpose
Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak +10 morewiley +1 more source
