Results 41 to 50 of about 20,851 (255)
Dynamic Search of Train Shortest Routes Within Microscopic Traffic Simulators
IEEE Access, 2022 Computer simulations are frequently used for rail traffic optimization. This approach, referred to as simulation-based optimization, typically employs simulation tools – simulators that are designed to examine railway systems at various levels of ...
Antonin Kavicka, Roman Divis
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Impact of wheel shape on the vertical damage of cast crossing panels in turnouts [PDF]
, 2015 Impact forces generated in the load transfer area of railway crossing panels lead to a range of degradation modes from wear and fatigue of the contacting materials, fatigue of supporting components to ballast/subgrade deterioration.
Bezin, Yann +3 more
core
Exponential sensitivity of noise-driven switching in genetic networks [PDF]
, 2008 Cells are known to utilize biochemical noise to probabilistically switch between distinct gene expression states. We demonstrate that such noise-driven switching is dominated by tails of probability distributions and is therefore exponentially sensitive ...
Mehta, Pankaj +2 more
core +3 more sources
Cross-selling, switching costs and imperfect competition in British banks [PDF]
Journal of Banking & Finance, 2011 This paper attempts to evaluate the competitiveness of British banking in the presence of cross-selling and switching costs during 1993–2008. It presents estimates of a model of banking behaviour that encompasses switching costs as well as cross-selling of loans and off-balance sheet transactions.
Zhao, Tianshu +2 more
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Two Modes of Magnetization Switching in a Simulated Iron Nanopillar in an Obliquely Oriented Field
, 2007 Finite-temperature micromagnetics simulations are employed to study the magnetization-switching dynamics driven by a field applied at an angle to the long axis of an iron nanopillar.
+12 more
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Computing Homology Invariants of Legendrian Knots
, 2014 The Chekanov-Eliashberg differential graded algebra of a Legendrian knot L is a rich source of Legendrian knot invariants, as is the theory of generating families.
Casey, Emily E., Henry, Michael B.
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source