Results 51 to 60 of about 20,901 (271)

Condition Monitoring of Railway Crossing Geometry via Measured and Simulated Track Responses

Sensors, 2022
This paper presents methods for continuous condition monitoring of railway switches and crossings (S&C, turnout) via sleeper-mounted accelerometers at the crossing transition. The methods are developed from concurrently measured sleeper accelerations and
Marko D. G. Milosevic, Björn A. Pålsson, Arne Nissen, Jens C. O. Nielsen, Håkan Johansson   +4 more
doaj   +1 more source

Architectures and Buffering for All-Optical Packet-Switched Cross-Connects [PDF]

Photonic Network Communications, 2006
This paper considers the performance of an all-optical packet-switched cross-connect. All-optical header processing and all-optical routing are implemented in the cross-connect architectures. The main metric considered to measure the performance is the packet loss ratio for the buffering. This is influenced primarily by three factors.
Geldenhuys, R., Liu, Y., Hill, M.T., Khoe, G.D., Leuschner, F.W., Dorren, H.J.S.   +5 more
openaire   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Two railway circuits: a universal circuit and an NP-difficult one [PDF]

Computer Science Journal of Moldova, 2001
In this paper, first we construct a railway circuit based on three types of switches and on crossings. Such a circuit is able to simulate the computation of any Turing machine, in particular of a universal one. That result was proved by Ian Stewart in [3]
Maurice Margenstern
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Legendrian and transverse twist knots

, 2011
In 1997, Chekanov gave the first example of a Legendrian nonsimple knot type: the $m(5_2)$ knot. Epstein, Fuchs, and Meyer extended his result by showing that there are at least $n$ different Legendrian representatives with maximal Thurston--Bennequin ...
Etnyre, John B., Ng, Lenhard L., Vertesi, Vera   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Two Modes of Magnetization Switching in a Simulated Iron Nanopillar in an Obliquely Oriented Field

, 2007
Finite-temperature micromagnetics simulations are employed to study the magnetization-switching dynamics driven by a field applied at an angle to the long axis of an iron nanopillar.
, Aharoni A, Brown W F, G Brown, Greengard L F, Iosifescu M, Kolesik M, M A Novotny, Novotny M A, P A Rikvold, Press W, S H Thompson, Thompson S H   +12 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source