Results 71 to 80 of about 20,901 (271)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Experiences Using MEMS Accelerometers on Railway Bearers at Switches and Crossings to Obtain Displacement—Awkward Situations

Infrastructures
A sleeper, or more generally a “bearer”, moves vertically under a passing train load. The extent of this motion depends on the static and dynamic load of the train, the train speed, and the support conditions at the bearer and its neighbours.
Jou-Yi Shih, Paul Weston, Mani Entezami, Clive Roberts, Mark O’Callaghan   +4 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Wear and Plasticity in Railway Turnout Crossings: A Fast Semi-Physical Model to Replace FE Simulations

Machines
Severe changes in the profiles of the crossing nose are caused by large dynamic contact forces. To predict these forces as well as the profile evolution, the Whole System Model (WSM) was developed.
Hamed Davoodi Jooneghani, Kamil Sazgetdinov, Alexander Meierhofer, Stephan Scheriau, Uwe Ossberger, Gabor Müller, Klaus Six   +6 more
doaj   +1 more source

The correspondence between augmentations and rulings for Legendrian knots

, 2005
We strengthen the link between holomorphic and generating-function invariants of Legendrian knots by establishing a formula relating the number of augmentations of a knot's contact homology to the complete ruling invariant of Chekanov and Pushkar.Comment:
Joshua, Lenhard L. Ng, M. Sabloff
core   +2 more sources

Finite Type Invariants of w-Knotted Objects II: Tangles, Foams and the Kashiwara-Vergne Problem [PDF]

, 2014
This is the second in a series of papers dedicated to studying w-knots, and more generally, w-knotted objects (w-braids, w-tangles, etc.). These are classes of knotted objects that are wider but weaker than their "usual" counterparts.
Bar-Natan, Dror, Dancso, Zsuzsanna
core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Validation, interpretation and use of railway track acceleration data

Transportation Engineering
It has for many years been relatively straightforward to attach an accelerometer to a railway track and obtain data of track accelerations as trains pass.
William Powrie, David Milne, Geoff Watson, Ben Lee, Louis Le Pen   +4 more
doaj   +1 more source

The Bennequin number, Kauffman polynomial, and ruling invariants of a Legendrian link: the Fuchs conjecture and beyond

, 2005
We show that the ungraded ruling invariants of a Legendrian link can be realized as certain coefficients of the Kauffman polynomial which are non-vanishing if and only if the upper bound for the Bennequin number given by the Kauffman polynomial is sharp.
Rutherford, Dan
core