Results 121 to 130 of about 3,245,214 (331)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

AN ANALYSIS ON CODE-SWITCHING USED BY PRESENTERS OF “MTV WHAT`S UP” ENTERTAINMENT NEWS PROGRAMON GLOBAL TV [PDF]

open access: yes, 2005
Code switching is a bilingual communication strategy consisting of the alternative use of two languages in the same utterance. The main objective of this study is an analysis on code switching used by presenters of MTV WHAT`S UP entertainment news ...
NOVANTRI, IIN
core  

Phase Coherent Precessional Magnetization Reversal in Micro-scopic Spin Valve Elements

open access: yes, 2002
We study the precessional switching of the magnetization in microscopic spin valve cells induced by ultra short in-plane hard axis magnetic field pulses. Stable and highly efficient switching is monitored following pulses as short as 140 ps with energies
B. Hillebrands   +11 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Directional optical switching and transistor functionality using optical parametric oscillation in a spinor polariton fluid

open access: yes, 2017
Over the past decade, spontaneously emerging patterns in the density of polaritons in semiconductor microcavities were found to be a promising candidate for all-optical switching.
Binder, Rolf   +6 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Channel-Adaptive Space-Collaborative Constellation Design for MIMO VLC With Fast Maximum Likelihood Detection

open access: yesIEEE Access, 2017
Multi-input multi-output (MIMO) holds great potential in the high-speed transmission of visible light communication (VLC). However, as for the current MIMO-VLC techniques, the error performance is improved by wasting spatial resources, which just drops ...
Ke Xu   +3 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

Code Switching in Social Media Twitter [PDF]

open access: yes, 2014
The study deals with the types of code switching and reasons why people switch their language in social media Twitter. The objectives of study are to find out contextual type and the grammatical type of code-switching which is mostly used in social media
Meisuri, M. (Meisuri)   +1 more
core  

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

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