Results 101 to 110 of about 776,968 (306)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Frequency Switching for Simultaneous Wireless Information and Power Transfer

, 2016
A new frequency switching receiver structure is proposed for simultaneous wireless information and power transfer in multi-carrier communication systems.
Altinel, Dogay, Kurt, Gunes Karabulut
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Online Monitoring Method for IGBT Bond-Wire Lift-Off of Electric Vehicles via Phase-Current Spectral Analysis

IEEE Access
Insulated gate bipolar transistors (IGBTs) are vulnerable components in electrified powertrain systems, considerably influencing inverter reliability and operational lifespan. Among their various failure mechanisms, bond-wire lift-off is a common package-
Jingyu Noh, Jeonghae Lee, Jaewook Oh, Jeonghoon Kang, Namsu Kim   +4 more
doaj   +1 more source

Nematic Liquid Crystal Composite Materials for DC and RF Switching [PDF]

, 2019
Liquid Crystals (LCs) are widely used in display devices, electro-optic modulators, and optical switches. A field-induced electrical conductivity modulation in pure liquid crystals is very low which makes it less preferable for direct current (DC) and ...
Anwar, Farhana, Coutu, Ronald A., Jr., Munna, Mohiuddin   +2 more
core   +1 more source

High frequency polarization switching of a thin ferroelectric film

, 2010
We consider both experimentally and analytically the transient oscillatory process that arises when a rapid change in voltage is applied to a $Ba_xSr_{1-x}TiO_3$ ferroelectric thin film deposited on an $Mg0$ substrate. High frequency ($\approx 10^{8} rad/
A. F. Devonshire, A. I. Maimistov, E. D. Mishina, E. V. Kazantseva, G. A. Smolensky, J.-G. Caputo, L. D. Landau, L. Landau, O. Vendik, V. L. Ginzburg, V. L. Ginzburg, V. M. Mukhortov, Yu. I. Balkarei   +12 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

High Precision Astrometric Millimeter VLBI Using a New Method for Atmospheric Calibration

, 2011
We describe a new method which achieves high precision Very Long Baseline Interferometry (VLBI) astrometry in observations at millimeter wavelengths.
Alef, Asaki, Asaki, Beasley, Dodson, Dodson, Falcke, Fomalont, Honma, Honma, Jung, Lobanov, M. Rioja, Porcas, Porcas, Porcas, Porcas, R. Dodson, Reid, Rioja, Rioja, Rioja, Rioja, Rioja, Rioja, Thompson, Ulvestad, Walker   +27 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source