Results 121 to 130 of about 776,968 (306)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Analysis and Suppression of Harmonic Deteriorations Related to a Few-Submodule and Low-Switching-Frequency MMC-Based UPFC

open access: yesIEEE Access
System efficiency, power quality, and economic benefits have always been essential for the Unified Power Flow Controller (UPFC based on a Modular Multilevel Converter (MMC). This paper proposes a low-switching-frequency MMC-UPFC operation scheme based on
Zhijun Chen   +7 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Proposal for ultrafast switching of ferroelectrics using mid-infrared pulses

open access: yes, 2015
I propose a method for ultrafast switching of ferroelectric polarization using mid-infrared pulses. This involves selectively exciting the highest frequency $A_1$ phonon mode of a ferroelectric material with an intense mid-infrared pulse. Large amplitude
Subedi, Alaska
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

An Improved Multiobjective Model-Predictive Control Method for Active Neutral-Point-Clamped Five-Level Converter

open access: yesIEEE Open Journal of the Industrial Electronics Society
The active neutral-point-clamped five-level converter has drawn much attention in industrial applications. However, common-mode voltage (CMV) suppression, accurate track current, fixed switching frequencies, neutral-point (NP) voltage balance, and flying
Qiguang Ren   +4 more
doaj   +1 more source

Frequency-switching speed and post-tuning drift measurement of fast-switching microwave-frequency synthesisers

open access: yesIET Science, Measurement & Technology, 2007
Frequency-switching speed is a critical parameter in many communication systems, target detection as well as in automated test systems. Measuring frequency-switching speed is necessary to determine the suitability of the frequency synthesiser for a particular application. In this paper, a method for measuring frequency-switching speed of fast-switching
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

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