Results 61 to 70 of about 819,402 (298)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Assessment of the Power Losses in a SAE J2954-Compliant Wireless Charger

IEEE Access, 2022
Electric Vehicles are a realistic and sustainable alternative to traditional vehicles. However, their autonomy is still perceived as a strong limitation. To overcome it, new and simpler methods for charging must be provided.
Jose M. Gonzalez-Gonzalez, Alicia Trivino-Cabrera, Jose A. Aguado   +2 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Relabelling Algorithms for Large Dataset Mixture Models [PDF]

, 2014
Mixture models are flexible tools in density estimation and classification problems. Bayesian estimation of such models typically relies on sampling from the posterior distribution using Markov chain Monte Carlo.
Fan, Yanan, Zhu, Wanchuang
core  

Wave scattering on a domain wall in a chain of PT-symmetric couplers

, 2012
We study wave propagation in linear arrays composed of pairs of conjugate waveguides with balanced gain and loss, i.e. arrays of the PT-symmetric couplers, where the linear spectrum is known to feature high-frequency and low-frequency branches.
Dmitriev, Sergey V., Kivshar, Yuri S., Malomed, Boris A., Suchkov, Sergey V.   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Dual-Transformer Series Resonant Converter with Full Range ZVS Operation

Shanghai Jiaotong Daxue xuebao
A dual-transformer series resonant converter (DTSRC) is proposed to solve the problem of excessive return power and loss of zero voltage switching (ZVS) operation under light load in the dual bridge resonant converter (DBRC). A dual-transformer structure
LI Yinan, HU Song, LI Xiaodong, CHEN Wu, ZHONG Liping, YANG Qingqing
doaj   +1 more source

Analysis of Switching-Loss-Reduction Methods for MHz-Switching Buck Converters [PDF]

2007 IEEE Conference on Electron Devices and Solid-State Circuits, 2007
Numbers of switching-loss-reduction methods recently proposed for MHz-switching buck converters are thoroughly investigated. From a theoretical perspective, switching loss is found to be effectively minimized by adapting the width rather than the turn-on voltage of power transistors of a buck converter.
Tsz Yin Man, Philip K. T. Mok, Mansun Chan   +2 more
openaire   +1 more source

Bistability loss as key feature in azobenzene (non-)switching on metal surfaces

, 2012
Coinage metal adsorbed azobenzene is investigated as prototypical molecular switch. It is shown that switching capabilities are not just lost due to excited state quenching, but already due to changes in the ground state energetics.
Maurer, Reinhard J., Reuter, Karsten
core   +1 more source