Results 71 to 80 of about 819,402 (298)

In-band label extractor based on Cascaded Si ring resonators enabling 160 Gb/s optical packet switching modules [PDF]

, 2014
Photonic integration of optical packet switching modules is crucial to compete with existing electronic switching fabrics in large data center networks.
Calabretta, Nicola, De Heyn, Peter, Di Lucente, Stefano, Dorren, Harm JS, Luo, Jun, Van Thourhout, Dries   +5 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Low-loss AlInN/GaN microwave switch

Electronics Letters, 2011
A report is presented on the first low-loss monolithic microwave integrated circuit switch using AlInN/GaN heterostructure field effect transistors. Owing to significantly lower sheet resistance compared to the conventional AlGaN/GaN heterostructure (215 against 280 Q/□), and lower contact resistance (0.27 against 0.5 Ω×mm), the microwave switch based ...
A. Sattu, D. Billingsley, J. Deng, J. Yang, G. Simin, M. Shur, R. Gaska   +6 more
openaire   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Discontinuous PWM Strategy for Neutral Point Clamped Three-Level Inverter to Achieve Multiple Control Objectives

IEEE Access, 2019
In order to reduce switching loss of neutral-point clamped (NPC) three-level inverter (TLI), a switching loss minimized discontinuous PWM (SLMDPWM) strategy is proposed firstly.
Jinping Wang, Wei Zhang, Mingna Ma, Qingyan Zhang, Weidong Jiang   +4 more
doaj   +1 more source

Loss Jump During Loss Switch in Solving PDEs with Neural Networks

Communications in Computational Physics
Using neural networks to solve partial differential equations (PDEs) is gaining popularity as an alternative approach in the scientific computing community. Neural networks can integrate different types of information into the loss function. These include observation data, governing equations, and variational forms, etc.
Wang, Zhiwei, Zhang, Lulu, Zhang, Zhongwang, Xu, Zhi-Qin John   +3 more
openaire   +2 more sources

Fast polarization insensitive optical shutters using dual frequency liquid crystals [PDF]

, 2014
Most of the existing displays and optical shutters based on liquid crystals work in combination with linear polarizers. This implies that often more than half of the light is lost due to optical loss in the polarizers and/or the fact that the incoming ...
Beeckman, Jeroen, Chojnowska, Olga, Dabrowski, Roman, Kim, JDK, Mangelinckx, Glenn, Neyts, Kristiaan, Shin, J   +6 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source