Results 81 to 90 of about 35,558 (271)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Switched after Birth: Performance of the Viburnum Leaf Beetle [Pyrrhalta viburni (Paykull)] after Transfer to a Suboptimal Host Plant

Insects, 2014
Host plant switching is common among phytophagous insects. Once optimal food sources have been depleted, immature insects may resort to use of suboptimal hosts in order to complete their development. Such host switching may have dramatic consequences for
Gaylord A. Desurmont, Paul A. Weston
doaj   +1 more source

Partial root drying in the cultivation of barbados cherry under chapada Diamantina biome conditions.

, 2015
A utilização eficaz da água tem se tornado uma componente chave na produção de alimentos e da alta qualidade dos produtos nas regiões áridas e semiáridas, devido à crescente falta de recursos hídricos disponíveis. O déficit hídrico pode provocar diversas
CARVALHO, Gian Carlo
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Transcriptional Switches Direct Plant Organ Formation and Patterning [PDF]

, 2012
Development of multicellular organisms requires specification of diverse cell types. In plants, development is continuous and because plant cells are surrounded by rigid cell walls, cell division and specification of daughter cell fate must be carefully orchestrated.
Miguel A, Moreno-Risueno, Jaimie M, Van Norman, Philip N, Benfey   +2 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

THE EFFECTIVENESS OF THE REPLACEMENT LOW-VOLTAGE SWITCHING DEVICES ON THE EXAMPLE OF INDUSTRIAL ENTERPRISE

Известия высших учебных заведений: Проблемы энергетики, 2017
The article is devoted to evaluating the effectiveness of replacing installed in the workshop network of low-voltage switching devices for new in order to reduce electricity consumption in an industrial plant. The dynamics of change in the relative power
A. V. Shagidullin
doaj   +1 more source

Laboratory studies examining aspects of scent marking, traplining and remote detection of reward in the foraging bumblebee.

, 2007
PhDEnergy from food is essential for the survival of all animals. For decades, bumblebees have been used as model organisms for studying animal foraging strategies.
Saleh, Nehal
core