Results 41 to 50 of about 1,925,380 (293)

An Improved Transformer Framework for Well-Overflow Early Detection via Self-Supervised Learning

Energies, 2022
Oil drilling has always been considered a vital part of resource exploitation, and during which overflow is the most common and tricky threat that may cause blowout, a catastrophic accident. Therefore, to prevent further damage, it is necessary to detect
Wan Yi, Wei Liu, Jiasheng Fu, Lili He, Xiaosong Han   +4 more
doaj   +1 more source

Dual Semi-Supervised Learning for Classification of Alzheimer’s Disease and Mild Cognitive Impairment Based on Neuropsychological Data

Brain Sciences, 2023
Deep learning has shown impressive diagnostic abilities in Alzheimer’s disease (AD) research in recent years. However, although neuropsychological tests play a crucial role in screening AD and mild cognitive impairment (MCI), there is still a lack of ...
Yan Wang, Xuming Gu, Wenju Hou, Meng Zhao, Li Sun, Chunjie Guo   +5 more
doaj   +1 more source

Operators of subprincipal type

, 2016
In this paper we consider the solvability of pseudodifferential operators when the principal symbol vanishes of at least second order at a non-radial involutive manifold $\Sigma_2$.
Dencker, Nils
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

NCResNet: Noncoding Ribonucleic Acid Prediction Based on a Deep Resident Network of Ribonucleic Acid Sequences

Frontiers in Genetics, 2020
Noncoding RNA (ncRNA) is a kind of RNA that plays an important role in many biological processes, diseases, and cancers, while cannot translate into proteins.
Sen Yang, Yan Wang, Yan Wang, Shuangquan Zhang, Xuemei Hu, Qin Ma, Yuan Tian   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Narrative Potential of Picture-Book Apps: A Media- and Interaction-Oriented Study

Frontiers in Psychology, 2020
Digital literature is playing an increasingly important role in children's everyday lives and opening up new paths for family literacy and early childhood education.
Claudia Müller-Brauers, Christiane Miosga, Silke Fischer, Alina Maus, Alina Maus, Ines Potthast   +5 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Indoor localization algorithm based on artificial neural network and radio-frequency identification reference tags

Advances in Mechanical Engineering, 2018
With the development of Internet of Things technology, radio-frequency identification localization methods have been widely applied due to their low cost and ease of deployment.
Quangang Wen, Yanchun Liang, Chunguo Wu, Adriano Tavares, Xiaosong Han   +4 more
doaj   +1 more source