Results 51 to 60 of about 493,316 (299)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Dual Semi-Supervised Learning for Classification of Alzheimer’s Disease and Mild Cognitive Impairment Based on Neuropsychological Data

Brain Sciences, 2023
Deep learning has shown impressive diagnostic abilities in Alzheimer’s disease (AD) research in recent years. However, although neuropsychological tests play a crucial role in screening AD and mild cognitive impairment (MCI), there is still a lack of ...
Yan Wang, Xuming Gu, Wenju Hou, Meng Zhao, Li Sun, Chunjie Guo   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

NCResNet: Noncoding Ribonucleic Acid Prediction Based on a Deep Resident Network of Ribonucleic Acid Sequences

Frontiers in Genetics, 2020
Noncoding RNA (ncRNA) is a kind of RNA that plays an important role in many biological processes, diseases, and cancers, while cannot translate into proteins.
Sen Yang, Yan Wang, Yan Wang, Shuangquan Zhang, Xuemei Hu, Qin Ma, Yuan Tian   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Near-Capacity Irregular Convolutional Coded Cooperative Differential Linear Dispersion Codes Using Multiple-Symbol Differential Decoding Aided Non-coherent Detection [PDF]

, 2011
We propose a novel near-capacity Multiple-Symbol Differential Decoding (MSDD) aided cooperative Differential Linear Dispersion Code (DLDC) scheme, which exhibits a high grade of system design flexibility in terms of relays selection and rate allocation ...
Ng, Soon, Soon Xin Ng, Chao Xu, Xu, Chao, Hanzo, Lajos, Lajos Hanzo   +5 more
core   +2 more sources

Indoor localization algorithm based on artificial neural network and radio-frequency identification reference tags

Advances in Mechanical Engineering, 2018
With the development of Internet of Things technology, radio-frequency identification localization methods have been widely applied due to their low cost and ease of deployment.
Quangang Wen, Yanchun Liang, Chunguo Wu, Adriano Tavares, Xiaosong Han   +4 more
doaj   +1 more source

Narrative Potential of Picture-Book Apps: A Media- and Interaction-Oriented Study

Frontiers in Psychology, 2020
Digital literature is playing an increasingly important role in children's everyday lives and opening up new paths for family literacy and early childhood education.
Claudia Müller-Brauers, Christiane Miosga, Silke Fischer, Alina Maus, Alina Maus, Ines Potthast   +5 more
doaj   +1 more source

Symbol of dream on santiago's life in paulo coelho's in the alchemist [PDF]

, 2019
This thesis studied about the analysis of Symbol of Dream on Santiago's Life in Paulo Coelho's the Alchemist. The aims of this research to find out of symbol in novel the Alchemist. This research used descriptive method and semiotic approach in analyzing
Baedori, Adi, Adi Baedori
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source