Results 51 to 60 of about 503,114 (301)

Narrative Potential of Picture-Book Apps: A Media- and Interaction-Oriented Study

Frontiers in Psychology, 2020
Digital literature is playing an increasingly important role in children's everyday lives and opening up new paths for family literacy and early childhood education.
Claudia Müller-Brauers, Christiane Miosga, Silke Fischer, Alina Maus, Alina Maus, Ines Potthast   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Near-Capacity Irregular Convolutional Coded Cooperative Differential Linear Dispersion Codes Using Multiple-Symbol Differential Decoding Aided Non-coherent Detection [PDF]

, 2011
We propose a novel near-capacity Multiple-Symbol Differential Decoding (MSDD) aided cooperative Differential Linear Dispersion Code (DLDC) scheme, which exhibits a high grade of system design flexibility in terms of relays selection and rate allocation ...
Ng, Soon, Xu, Chao, Hanzo, Lajos
core   +2 more sources

An Image Histogram Equalization Acceleration Method for Field-Programmable Gate Arrays Based on a Two-Dimensional Configurable Pipeline

Sensors
New artificial intelligence scenarios, such as high-precision online industrial detection, unmanned driving, etc., are constantly emerging and have resulted in an increasing demand for real-time image processing with high frame rates and low power ...
Yan Wang, Peirui Liu, Dalin Li, Kangping Wang, Rui Zhang   +4 more
doaj   +1 more source

Symbolic Behavior in Regular Classrooms: A Specification of Symbolic and Non-Symbolic Behavior [PDF]

Frontiers in Psychology, 2011
Students' capabilities to use symbolic information in classroom setting could be expected to influence their possibilities to be active and participating. The development of strategies for teachers to compensate for reduced capability need specific operational definition of symbolic behavior.
Billinger, Stefan, Norlander, Torsten
openaire   +5 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

MMGAT: a graph attention network framework for ATAC-seq motifs finding

BMC Bioinformatics
Background Motif finding in Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) data is essential to reveal the intricacies of transcription factor binding sites (TFBSs) and their pivotal roles in gene regulation.
Xiaotian Wu, Wenju Hou, Ziqi Zhao, Lan Huang, Nan Sheng, Qixing Yang, Shuangquan Zhang, Yan Wang   +7 more
doaj   +1 more source

Relating brain structure images to personality characteristics using 3D convolution neural network

CAAI Transactions on Intelligence Technology, 2021
The Keras deep learning framework is employed to study MRI brain data in a preliminary analysis of brain structure using a convolutional neural network. The results obtained are matched with the content of personality questionnaires.
Lixian Cao, Yanchun Liang, Wei Lv, Kaechang Park, Yasuhiro Miura, Yuki Shinomiya, Shinichi Yoshida   +6 more
doaj   +1 more source