Results 71 to 80 of about 428,043 (317)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
International Journal of Genomics, 2016 More and more studies have demonstrated that long noncoding RNAs (lncRNAs) play critical roles in diversity of biological process and are also associated with various types of disease.
Siyu Han, Yanchun Liang, Ying Li, Wei Du
doaj +1 more source
Complex & Intelligent Systems, 2023 Analyzing highly individual-specific genomic data to understand genetic interactions in cancer development is still challenging, with significant implications for the discovery of individual biomarkers as well as personalized medicine.
Wenju Hou +5 more
doaj +1 more source
Multilayer Perceptron Network Optimization for Chaotic Time Series Modeling
Entropy, 2023 Chaotic time series are widely present in practice, but due to their characteristics—such as internal randomness, nonlinearity, and long-term unpredictability—it is difficult to achieve high-precision intermediate or long-term predictions.
Mu Qiao +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
The Field of Norms Functor and the Hilbert Symbol [PDF]
, 2010 The classical Hilbert symbol of a higher local field $F$ containing a primitive $p^M$-th root of unity $\zeta_M$ is a pairing $F^*/(F^*)^{p^M}\times K_N(F)/p^M \to \mu_{p^M}$, describing Kummer extensions of exponent $p^M$.
JENNI, RUTH,CHRISTINE +1 more
core
Prior-guided attention fusion transformer for multi-lesion segmentation of diabetic retinopathy
Scientific ReportsTo solve the issue of diagnosis accuracy of diabetic retinopathy (DR) and reduce the workload of ophthalmologists, in this paper we propose a prior-guided attention fusion Transformer for multi-lesion segmentation of DR.
Chenfangqian Xu +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
On the complexity of unary error correction codes for the near-capacity transmission of symbol values from an infinite set [PDF]
, 2013 Unary Error Correction (UEC) codes have recently been proposed for the near-capacity Joint Source and Channel Coding (JSCC) of symbol values that are selected from a set having an infinite cardinality.
Robert G. Maunder +5 more
core +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source