Results 71 to 80 of about 1,958,622 (342)
ACPNet: A Deep Learning Network to Identify Anticancer Peptides by Hybrid Sequence Information
Molecules, 2022 Cancer is one of the most dangerous threats to human health. One of the issues is drug resistance action, which leads to side effects after drug treatment. Numerous therapies have endeavored to relieve the drug resistance action.
Mingwei Sun +3 more
doaj +1 more source
Metric and Color Modifications for the Automated Construction of Map Symbols [PDF]
, 2023 Xinyu Gong, Tian Lan, Peng Ti
openalex +1 more source
Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations
FEBS Open Bio, EarlyView.Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro +8 more
wiley +1 more source
Prior-guided attention fusion transformer for multi-lesion segmentation of diabetic retinopathy
Scientific ReportsTo solve the issue of diagnosis accuracy of diabetic retinopathy (DR) and reduce the workload of ophthalmologists, in this paper we propose a prior-guided attention fusion Transformer for multi-lesion segmentation of DR.
Chenfangqian Xu +7 more
doaj +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive impairment (CI) affects the quality of life in multiple sclerosis (MS). Identifying influencing factors is key to improving CI monitoring. This systematic review and meta‐analysis examines clinical and sociodemographic variables impacting the cognitive screening Symbol Digit Modalities Test (SDMT) performance across MS ...
Katalin Lugosi +8 more
wiley +1 more source
Acupuncture and tuina knowledge graph with prompt learning
Frontiers in Big DataIntroductionAcupuncture and tuina, acknowledged as ancient and highly efficacious therapeutic modalities within the domain of Traditional Chinese Medicine (TCM), have provided pragmatic treatment pathways for numerous patients. To address the problems of
Xiaoran Li +5 more
doaj +1 more source
Symbol Grounding and the Symbolic Theft Hypothesis [PDF]
, 2002 Scholars studying the origins and evolution of language are also interested in the general issue of the evolution of cognition. Language is not an isolated capability of the individual, but has intrinsic relationships with many other behavioral, cognitive, and social abilities.
Cangelosi, Angelo +2 more
openaire +4 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini +7 more
wiley +1 more source