Results 41 to 50 of about 22,340,656 (310)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Time Series Complexities and Their Relationship to Forecasting Performance
Entropy, 2020 Entropy is a key concept in the characterization of uncertainty for any given signal, and its extensions such as Spectral Entropy and Permutation Entropy. They have been used to measure the complexity of time series.
Mirna Ponce-Flores +4 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Numerical and Symbolic Computation [PDF]
, 2020 This book is a comprehensive set of articles reflecting on the application of symbolic and/or numerical computation in a range of scientific areas within the fields of engineering and science. These articles constitute extended versions of communications
core +2 more sources
Identifying Ordinal Similarities at Different Temporal Scales
EntropyThis study implements the permutation Jensen–Shannon distance as a metric for discerning ordinal patterns and similarities across multiple temporal scales in time series data.
Luciano Zunino +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Symbolic Analysis of OTRAs-Based Circuits [PDF]
, 2011 A new nullor-based model to describe the behavior of Operational Transresistance Amplifiers (OTRAs) is introduced. The new model is composed of four nullors and three grounded resistors. As a consequence, standard nodal analysis can be applied to compute
ESTEBAN TLELO CUAUTLE +2 more
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
The Auspicious Couple: Symbolic Execution and WCET Analysis [PDF]
, 2013 We have recently shown that symbolic execution together with the implicit path enumeration technique can successfully be applied in the Worst-Case Execution Time (WCET) analysis of programs.
Kovacs, Laura, +11 more
core +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source