Results 41 to 50 of about 55,219 (268)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Aesthetics of Korean foods: The symbol of Korean culture

open access: yesJournal of Ethnic Foods, 2016
Advances in transportation and communication have broken down critical barriers within the global economy, pushing us towards a more unified world.
Hae-Kyung Chung   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Numerical and experimental study of the effects of noise on the permutation entropy

open access: yesNew Journal of Physics, 2015
We analyze the effects of noise on the permutation entropy of dynamical systems. We take as numerical examples the logistic map and the Rössler system.
C Quintero-Quiroz   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

"Suure tamme" laul - süntees [PDF]

open access: yesMäetagused, 2011
A cyclic space-time concept in which one cycle corresponds to one year, can be used as a basis for an integral theory of a mythic world-and-time tree.
Matej Goršič
doaj  

Symbolic Analysis of the Cycle-to-Cycle Variability of a Gasoline–Hydrogen Fueled Spark Engine Model

open access: yesEnergies, 2018
An study of temporal organization of the cycle-to-cycle variability (CCV) in spark ignition engines fueled with gasoline–hydrogen blends is presented. First, long time series are generated by means of a quasi-dimensional model incorporating the key
Israel Reyes-Ramírez   +5 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

A Semiotic Analysis of Chan Aesthetics in Chinese Animation: Reconstruction, Naturalisation, and Cultural Resonance

open access: yesArts
In recent years, Chinese animation has increasingly embraced traditional cultural elements, with Chan (Zen) Buddhism emerging as a rich source of philosophical and aesthetic inspiration.
Weihan Fang   +3 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

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