Results 51 to 60 of about 593,480 (290)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
On the Equivalence of Forward Mode Automatic Differentiation and Symbolic Differentiation
, 2020 We show that forward mode automatic differentiation and symbolic differentiation are equivalent in the sense that they both perform the same operations when computing derivatives.
Laue, Soeren
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Representación Simbólica de Preguntas: el proyecto ReSim [PDF]
Sintagma, 2006 Symbolic representation of questions: The ReSim Project. In this article we present the ReSim project: the symbolic representation of questions. The aim of this project was to create an automatic system capable of representing natural language questions ...
Ana Fernández Montraveta +2 more
doaj
Symbolic representation of scenarios in Bologna airport on virtual reality concept [PDF]
, 2017 This paper is a part of a big Project named Retina Project, which is focused in reduce the workload of an ATCO. It uses the last technological advances as Virtual Reality concept. The work has consisted in studying the different awareness situations that
Buyse Sánchez, Mercè +1 more
core
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Ta'dibMathematical semiotic representation is the ability to analyze and express mathematical ideas or notions of a phenomenon and everyday problem situations into the form of signs, images, symbols, and symbols that represent them and provide meaning and ...
Dwi Tri Fresti Firnanda, Indah Wahyuni
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Notes on narrative, cognition, and cultural evolution
Sign Systems Studies, 2016 Drawing on non-Darwinian cultural-evolutionary approaches, the paper develops a broad, non-representational perspective on narrative, necessary to account for the narrative “ubiquity” hypothesis.
Marina Grishakova, Siim Sorokin
doaj +1 more source