Results 51 to 60 of about 1,029,693 (348)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Men, Masculinities and Water Powers in Irrigation [PDF]
, 2008 The aim of this article is to provide an informed plea for more explicitly identifying, naming and unravelling the linkages between water control and gender in irrigation.
Zwarteveen, M.Z.
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Human Rights and Biopolitics between Sovereign Power, Domination and Genealogies [PDF]
, 2017 In Homo Sacer Agamben proposes a vision of politics as biopolitics since its Greek origins. While this new awareness becomes the conceptual domain in which re-interpret some political categories, at the same time it shows how sovereign power, in this ...
Castellani, Domenico
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The Illusion of Purity:Chantal Mouffe's Realist Critique of Cosmopolitanism [PDF]
, 2010 Over the last 20 years, cosmopolitan theories have been benefiting greatly from the dialogue between defenders and critics of world citizenship.
Thaler, Mathias
core +1 more source
The struggle for being in symbolic reality
Вестник Пермского университета. Философия. Психология. СоциологияThe purpose of the article is to explicate the concept of «being» in symbolic reality, to trace the reasons for the significant growth of interest in language, communicative space in modern philosophy, to show that the symbol not only acts as a means of communication but is the basis of a person’s creative attitude to reality.
Aleksander Yu. Ogorodnikov +1 more
openaire +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Making Reparations Possible: Theorizing Reparative Justice [PDF]
, 2015 Roll 125a. Quonsets coming down. Image 6 of 26. (11 April, 1954) [PHO 1.125a.6]The Boleslaus Lukaszewski (Father Luke) Photographs contain more than 28,000 images of Saint Louis University people, activities, and events between 1951 and 1970.
Walker, Margaret Urban
core +2 more sources