Results 31 to 40 of about 145,999 (267)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Bending strength of singly-symmetric overhanging floor I-beams

HBRC Journal, 2015
The design of the overhanging singly-symmetric I-beams is not sufficiently covered in the current standards and specifications. The buckling length coefficients specified in the current standards and specifications were firstly defined by Nethercot (1973)
A.K. Dessouki, A.B. AbdelRahim, D.O. Abdul Hameed   +2 more
doaj   +1 more source

Design of Symmetric-Key Primitives for Advanced Cryptographic Protocols

IACR Transactions on Symmetric Cryptology, 2020
While traditional symmetric algorithms like AES and SHA-3 are optimized for efficient hardware and software implementations, a range of emerging applications using advanced cryptographic protocols such as multi-party computation and zero knowledge proofs
Abdelrahaman Aly, Tomer Ashur, Eli Ben-Sasson, Alan Szepieniec   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Non-existence of quasi-symmetric designs having certain pseudo-geometric block graphs

AKCE International Journal of Graphs and Combinatorics
The block graph of a quasi-symmetric design is strongly regular. It is a challenging problem to decide which strongly regular graphs are block graphs of quasi-symmetric designs.
Kusum S. Rajbhar, Rajendra M. Pawale
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Extending symmetric designs

Journal of Combinatorial Theory, Series A, 1973
AbstractIf a symmetric 2-design with parameters (v, k, λ) is extendable, then one of the following holds: v = 4λ + 3, k = 2λ + 1; or v = (λ + 2)(λ2 + 4λ + 2), k = λ2 + 3λ + 1; or v = 111, k = 11, λ = 1; or v = 495, k = 39, λ = 3. In particular, there are at most three sets of extendable symmetric design parameters with any given value of λ.
openaire   +2 more sources

On symmetric and quasi-symmetric designs with the symmetric difference property and their codes

Journal of Combinatorial Theory, Series A, 1992
A symmetric 2-design has the symmetric difference property if the symmetric difference of any three blocks is either a block or the complement of a block. An infinite family of such designs is known which has parameters \((2^{2m},2^{2m-1}-2^{m-1},2^{2m-2}-2^{m- 1})\).
Jungnickel, Dieter, Tonchev, Vladimir D.
openaire   +1 more source

Structure and stability of the designer protein WRAP-T and its permutants

Scientific Reports, 2021
$$\beta $$ β -Propeller proteins are common natural disc-like pseudo-symmetric proteins that contain multiple repeats (‘blades’) each consisting of a 4-stranded anti-parallel $$\beta $$ β -sheet. So far, 4- to 12-bladed $$\beta $$ β -propellers have been
Bram Mylemans, Xiao Yin Lee, Ina Laier, Christine Helsen, Arnout R. D. Voet   +4 more
doaj   +1 more source