Results 21 to 30 of about 5,481 (126)
B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS [PDF]
, 2014 Activation of intrinsic growth programs that promote developmental axon growth may also facilitate axon regeneration in injured adult neurons. Here, we demonstrate that conditional activation of B-RAF kinase alone in mouse embryonic neurons is sufficient
Charron, Jean +12 more
core +1 more source
Monoaminergic Neuropathology in Alzheimer's disease [PDF]
, 2016 Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira +11 more
core +1 more source
Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels [PDF]
, 2015 Voltage-gated ion channels (VGICs) are membrane proteins that switch from a closed to open state in response to changes in membrane potential, thus enabling ion fluxes across the cell membranes.
Alessandro eMedoro +7 more
core +2 more sources
Functional Diversity of Neurotrophin Actions on the Oculomotor System [PDF]
, 2016 Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes.
Benítez Temiño, Beatriz +5 more
core +1 more source
What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? [PDF]
, 2013 Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell ...
Doñate-Macian, Pau +2 more
core +1 more source
Mechanisms of the gabapentinoids and α2δ-1 calcium channel subunit in neuropathic pain [PDF]
, 2016 The gabapentinoid drugs gabapentin and pregabalin are key front-line therapies for various neuropathies of peripheral and central origin. Originally designed as analogs of GABA, the gabapentinoids bind to the α2δ-1 and α2δ-2 auxiliary subunits of calcium
Dickenson, AH, Patel, RA
core +1 more source
Corneal nerves in health and disease [PDF]
, 2019 The cornea is the most sensitive structure in the human body. Corneal nerves adapt to maintain transparency and contribute to corneal health by mediating tear secretion and protective reflexes and provide trophic support to epithelial and stromal cells ...
Al Aqaba, Mouhamed A. +4 more
core +2 more sources
Clinical and Public Health Guidelines, Volume 2, Issue 4, October 2025.ABSTRACT Introduction Chronic pain affects 1 in 5 adults and children globally; however, management remains highly variable and low value care is common. Inconsistent recommendations among clinical practice guidelines for management of chronic pain contribute to suboptimal patient management.
Andrea J. Darzi +48 more
wiley +1 more source
[Reflex sympathetic dystrophy].
Acta Médica Portuguesa, 2011 Reflex Sympathetic Dystrophy is rare in pediatrics. It is a complex regional pain syndrome, of unknown etiology, usually post-traumatic, characterized by dysfunctions of the musculoskeletal, vascular and skin systems: severe persistent pain of a limb ...
Marta S. Oliveira +2 more
semanticscholar +1 more source
Systematic review and meta-analysis of genetic risk factors for neuropathic pain [PDF]
, 2018 Neuropathic pain (NP) is an increasingly common chronic pain state and a major health burden, affecting approximately 7-10% of the general population. Emerging evidence suggests that genetic factors could partially explain individual susceptibility to NP
Hébert, Harry L. +4 more
core +2 more sources