Results 191 to 200 of about 17,426,796 (291)

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

The sympathetic nervous system enhances host immune responses to enteric bacterial pathogens in mice. [PDF]

Brain Behav Immun
Tay E, Cremin M, Sanchez K, Llyod E, Brust-Mascher I, Reardon C.   +5 more
europepmc   +1 more source

Feasibility and Exploratory Outcomes of Foot‐Ankle and Walking Exercises for Diabetic Neuropathy, Stress, and Quality of Life: A Pilot Randomized Controlled Trial

Research in Nursing &Health, EarlyView.
ABSTRACT Foot–ankle and walking exercises have been proposed as potential strategies for managing symptoms in people with diabetic peripheral neuropathy (DPN), yet evidence from primary care remains limited. This pilot study assessed the feasibility and acceptability of these interventions and explored preliminary outcome patterns in DPN, stress, and ...
Siti Fadlilah, Wahyu Rochdiat Murdhiono, Ariyanto Nugroho, Yohanes Andy Rias, Shih Hsin Hsiao, Kai Ling Lee, Po Hao Feng, Hsiu Ting Tsai   +7 more
wiley   +1 more source

Chronically elevated sympathetic nervous system tone: A significant, common, and poorly realised contributor to cardiometabolic disease in type 2 diabetes. [PDF]

Diabetes Obes Metab
DeFronzo RA.
europepmc   +1 more source

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

Impact of sympathetic nervous system on immune evasion in high-grade serous ovarian cancer: a review. [PDF]

Front Oncol
Yu R, Li Y, Jiang R, Dang C, Zhai F.
europepmc   +1 more source

Atopic dermatitis and attention‐deficit/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management

Pediatric Investigation, EarlyView.
This review synthesizes epidemiological evidence linking atopic dermatitis to attention‐deficit/hyperactivity disorder in children, proposes an “inflammation‐itch‐neurobehavioral axis” integrating sleep disruption, neuroendocrine dysregulation, and emerging neuro‐immune circuits, and outlines multidisciplinary management strategies targeting both skin ...
Qingyang Zhao, Yuan Liang, Ying Liu, Chunping Shen, Mutong Zhao, Jing Tian, Lei Jiao, Jing Sun, Ying Gu, Qiong Wu, Shan Wang, Lin Ma   +11 more
wiley   +1 more source

Autonomic Neuroscience: Articles of interest appearing in other Frontiers journals

Frontiers in Neuroscience, 2012
Vaughan G Macefield, Joel C Bornstein
doaj   +1 more source

Effects of bariatric surgery upon the sympathetic nervous system and hypothalamic-pituitary-adrenal axis in obese humans. [PDF]

Sci Rep
Ziegler AK, Christensen M, Jørgensen HL, Fenger M, Myrup SF, Dirksen C, Madsbad S.   +6 more
europepmc   +1 more source

Transitioning to Higher Education: A Case Study of an Individual With Autism

Psychology in the Schools, EarlyView.
ABSTRACT Necessary arrangements should be made to enable university students with autism (the term “autism” is used to refer to the entire autism spectrum in this study) to improve their transition to university. The need for support may be higher in countries like Türkiye, where the number of university students with autism is relatively low, as ...
Mahmut Serkan Yazıcı, Şenay Baş, Mustafa Karnas   +2 more
wiley   +1 more source