Results 191 to 200 of about 3,868 (289)

Reversible cerebral vasoconstriction syndrome in a methylphenidate-treated patient: a case report. [PDF]

BMC Neurol
Osmont MN, Malrain C, Ruellan AL, Benchikh A, Herlem E, Polard E, Scailteux LM.   +6 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

LONG-ACTING SYMPATHOMIMETICS [PDF]

, 1992
Romain, Pauwels, Derom, Eric
core  

Thyrotoxic Periodic Paralysis (TPP): A Comprehensive Review with Regional Insights from the Middle East. [PDF]

Cureus
Alrashidi FS.
europepmc   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Renal Denervation for Uncontrolled Hypertension: A Measurement-First, Program-Based Approach. [PDF]

J Clin Med
Szarpak L, Katipoglu B, Jaguszewski MJ, Baier A, Kubica J, Maslyk M, Pruc M, Momot K, Cander B, Lin Q.   +9 more
europepmc   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, EarlyView.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Augmented Cardiac Inotropy by Phosphodiesterase Inhibition Requires Phosphorylation of Rad and Increased Calcium Current. [PDF]

Circulation
Katchman AN, Zakharov SI, Bohnen MS, Sanchez Jimenez A, Kushner JS, Yang L, Chen BX, Nasari A, Liu G, Rabbani DE, Han J, Leu CS, Pitt GS, Marx SO.   +13 more
europepmc   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Psychedelics for Depression: Between Hopes and Uncertainties.

Focus (Am Psychiatr Publ)
Suppes T, Fradet M.
europepmc   +1 more source