Results 11 to 20 of about 1,244,853 (318)

The hermeneutics of symptoms [PDF]

Medicine, Health Care and Philosophy, 2022
AbstractThe clinical encounter begins with presentation of an illness experience; but throughout that encounter, something else is constructed from it – a symptom. The symptom is a particular interpretation of that experience, useful for certain purposes in particular contexts.
Wardrope, A., Reuber, M.
openaire   +2 more sources

SPECIAL ISSUE: THE 50th ANNIVERSARY OF THE NATIONAL CANCER ACT OF 1971 - REVIEW - CANCER-RELATED FATIGUE: WHAT WE HAVE LEARNED AND WHAT ARE THE CHALLENGES FOR THE FUTURE

Journal of Cancer Rehabilitation, 2021
Although pain is the most feared symptomatic component of having cancer and being treated for it, cancer-related fatigue is the most severe and impairing symptom that cancer patients and cancer survivors face.
Xin Shelley Wang, Charles S Cleeland
doaj   +1 more source

Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats

Journal of Neuroinflammation, 2020
Background Production of inflammatory mediators by reactive microglial cells in the brain is generally considered the primary mechanism underlying the development of symptoms of sickness in response to systemic inflammation.
Elisabeth G. Vichaya, Sajida Malik, Luba Sominsky, Bianca G. Ford, Sarah J. Spencer, Robert Dantzer   +5 more
doaj   +1 more source

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

Acta Neuropathologica Communications, 2020
Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in vitro ...
Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen   +5 more
doaj   +1 more source

Tracking macrophages in diabetic neuropathy with two-color nanoemulsions for near-infrared fluorescent imaging and microscopy

Journal of Neuroinflammation, 2021
Background The incidence of diabetes and diabetic peripheral neuropathy continues to rise, and studies have shown that macrophages play an important role in their pathogenesis.
James M. Nichols, Caitlin V. Crelli, Lu Liu, Hoang Vu Pham, Jelena M. Janjic, Andrew J. Shepherd   +5 more
doaj   +1 more source

Sensory neuron dysfunction in orthotopic mouse models of colon cancer

Journal of Neuroinflammation, 2022
Reports of neurological sequelae related to colon cancer are largely restricted to rare instances of paraneoplastic syndromes, due to autoimmune reactions.
Mihály Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd   +11 more
doaj   +1 more source

Autoimmune regulation of chronic pain

PAIN Reports, 2021
. Chronic pain is an unpleasant and debilitating condition that is often poorly managed by existing therapeutics. Reciprocal interactions between the nervous system and the immune system have been recognized as playing an essential role in the initiation
Michael J. Lacagnina, Cobi J. Heijnen, Linda R. Watkins, Peter M. Grace   +3 more
doaj   +1 more source

Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

Acta Neuropathologica Communications, 2018
Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs transfer mitochondria to neural stem cells (NSCs) to protect NSCs against ...
Nabila Boukelmoune, Gabriel S. Chiu, Annemieke Kavelaars, Cobi J. Heijnen   +3 more
doaj   +1 more source

Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment

Acta Neuropathologica Communications, 2018
Chemotherapy-induced cognitive impairment (CICI) is a commonly reported neurotoxic side effect of chemotherapy, occurring in up to 75% cancer patients. CICI manifests as decrements in working memory, executive functioning, attention, and processing speed,
Jiacheng Ma, XiaoJiao Huo, Matthew B. Jarpe, Annemieke Kavelaars, Cobi J. Heijnen   +4 more
doaj   +1 more source

CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior

Neurobiology of Pain, 2020
Background: Chronic pain and depression often co-occur. The mechanisms underlying this comorbidity are incompletely understood. Here, we investigated the role of CD3+ T cells in an inflammatory model of comorbid persistent mechanical allodynia ...
Geoffroy Laumet, Jules D. Edralin, Robert Dantzer, Cobi J. Heijnen, Annemieke Kavelaars   +4 more
doaj   +1 more source