Results 21 to 30 of about 1,397,203 (301)

Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

Acta Neuropathologica Communications, 2018
Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs transfer mitochondria to neural stem cells (NSCs) to protect NSCs against ...
Nabila Boukelmoune, Gabriel S. Chiu, Annemieke Kavelaars, Cobi J. Heijnen   +3 more
doaj   +1 more source

Autoimmune regulation of chronic pain

PAIN Reports, 2021
. Chronic pain is an unpleasant and debilitating condition that is often poorly managed by existing therapeutics. Reciprocal interactions between the nervous system and the immune system have been recognized as playing an essential role in the initiation
Michael J. Lacagnina, Cobi J. Heijnen, Linda R. Watkins, Peter M. Grace   +3 more
doaj   +1 more source

CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior

Neurobiology of Pain, 2020
Background: Chronic pain and depression often co-occur. The mechanisms underlying this comorbidity are incompletely understood. Here, we investigated the role of CD3+ T cells in an inflammatory model of comorbid persistent mechanical allodynia ...
Geoffroy Laumet, Jules D. Edralin, Robert Dantzer, Cobi J. Heijnen, Annemieke Kavelaars   +4 more
doaj   +1 more source

Deconstructing therapy outcome measurement with Rasch analysis of a measure of general clinical distress: the Symptom Checklist-90-Revised [PDF]

, 2006
Rasch analysis was used to illustrate the usefulness of item-level analyses for evaluating a common therapy outcome measure of general clinical distress, the Symptom Checklist-90-Revised (SCL-90-R; Derogatis, 1994).
Beltyukova, Svetlana A., Gunderson, Jennifer, Fox, Christine M., Stone, Gregory E., Zhang, Xi, Elliott, Robert   +5 more
core   +4 more sources

Sensory neuron dysfunction in orthotopic mouse models of colon cancer

Journal of Neuroinflammation, 2022
Reports of neurological sequelae related to colon cancer are largely restricted to rare instances of paraneoplastic syndromes, due to autoimmune reactions.
Mihály Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd   +11 more
doaj   +1 more source

Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

Acta Neuropathologica Communications, 2022
Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities.
Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen   +9 more
doaj   +1 more source

Symptoms and symptom presentation

Scandinavian Journal of Primary Health Care, 1992
In the theory of medicine, symptoms are logically related to defined bodily derangements. In the practice of medicine, doctors see patients who experience and present their symptoms in a personal way. With the twofold aim of investigating the clinical significance of this gap and of tracing a practice oriented diagnostic competence, a study was ...
openaire   +2 more sources

Distinguishing symptom patterns in adults newly diagnosed with cancer: a latent class analysis

, 2022
Context: Socio-demographic differences, including place of residence, socio-economic status, ethnicity, and gender, have been associated with various inequities in cancer care outcomes.
Anis, A. H., Wallström, Sara,, Sawatzky, Richard,, Sutherland, J. M., Kopec, J. A.   +4 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Symptom Clusters and Relationships to Symptom Interference with Daily Life in Taiwanese Lung Cancer Patients

, 2008
The number one cause of cancer death in Taiwan is lung cancer. Of the few studies describing the experience of patients living with lung cancer, most use bivariate analyses to test associations between individual symptoms.
Tsai, Chun Ming, Lin, Chien Huang, Lin, Chia Chin, Chen, Bing Chang, Wang, Shu Yi   +4 more
core   +1 more source