Results 21 to 30 of about 1,019,147 (267)

Harnessing the placebo effect to enhance emotion regulation effectiveness and choice

Scientific Reports, 2023
The placebo effect demonstrates how positive expectancies shape the effectiveness of various treatments. Across studies, placebo treatments are interventions (creams, pills, etc.) that are presented to individuals as, and are learned to be, beneficial ...
Roni Shafir, Maya Israel, Luana Colloca
doaj   +1 more source

Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment

Acta Neuropathologica Communications, 2018
Chemotherapy-induced cognitive impairment (CICI) is a commonly reported neurotoxic side effect of chemotherapy, occurring in up to 75% cancer patients. CICI manifests as decrements in working memory, executive functioning, attention, and processing speed,
Jiacheng Ma, XiaoJiao Huo, Matthew B. Jarpe, Annemieke Kavelaars, Cobi J. Heijnen   +4 more
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Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats

Journal of Neuroinflammation, 2020
Background Production of inflammatory mediators by reactive microglial cells in the brain is generally considered the primary mechanism underlying the development of symptoms of sickness in response to systemic inflammation.
Elisabeth G. Vichaya, Sajida Malik, Luba Sominsky, Bianca G. Ford, Sarah J. Spencer, Robert Dantzer   +5 more
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Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

Acta Neuropathologica Communications, 2020
Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in vitro ...
Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen   +5 more
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Tracking macrophages in diabetic neuropathy with two-color nanoemulsions for near-infrared fluorescent imaging and microscopy

Journal of Neuroinflammation, 2021
Background The incidence of diabetes and diabetic peripheral neuropathy continues to rise, and studies have shown that macrophages play an important role in their pathogenesis.
James M. Nichols, Caitlin V. Crelli, Lu Liu, Hoang Vu Pham, Jelena M. Janjic, Andrew J. Shepherd   +5 more
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Autoimmune regulation of chronic pain

PAIN Reports, 2021
. Chronic pain is an unpleasant and debilitating condition that is often poorly managed by existing therapeutics. Reciprocal interactions between the nervous system and the immune system have been recognized as playing an essential role in the initiation
Michael J. Lacagnina, Cobi J. Heijnen, Linda R. Watkins, Peter M. Grace   +3 more
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Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

Acta Neuropathologica Communications, 2018
Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs transfer mitochondria to neural stem cells (NSCs) to protect NSCs against ...
Nabila Boukelmoune, Gabriel S. Chiu, Annemieke Kavelaars, Cobi J. Heijnen   +3 more
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CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior

Neurobiology of Pain, 2020
Background: Chronic pain and depression often co-occur. The mechanisms underlying this comorbidity are incompletely understood. Here, we investigated the role of CD3+ T cells in an inflammatory model of comorbid persistent mechanical allodynia ...
Geoffroy Laumet, Jules D. Edralin, Robert Dantzer, Cobi J. Heijnen, Annemieke Kavelaars   +4 more
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Sensory neuron dysfunction in orthotopic mouse models of colon cancer

Journal of Neuroinflammation, 2022
Reports of neurological sequelae related to colon cancer are largely restricted to rare instances of paraneoplastic syndromes, due to autoimmune reactions.
Mihály Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd   +11 more
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Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

Acta Neuropathologica Communications, 2022
Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities.
Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen   +9 more
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