Results 21 to 30 of about 1,976,623 (311)

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

Acta Neuropathologica Communications, 2020
Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in vitro ...
Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen   +5 more
doaj   +1 more source

Tracking macrophages in diabetic neuropathy with two-color nanoemulsions for near-infrared fluorescent imaging and microscopy

Journal of Neuroinflammation, 2021
Background The incidence of diabetes and diabetic peripheral neuropathy continues to rise, and studies have shown that macrophages play an important role in their pathogenesis.
James M. Nichols, Caitlin V. Crelli, Lu Liu, Hoang Vu Pham, Jelena M. Janjic, Andrew J. Shepherd   +5 more
doaj   +1 more source

Autoimmune regulation of chronic pain

PAIN Reports, 2021
. Chronic pain is an unpleasant and debilitating condition that is often poorly managed by existing therapeutics. Reciprocal interactions between the nervous system and the immune system have been recognized as playing an essential role in the initiation
Michael J. Lacagnina, Cobi J. Heijnen, Linda R. Watkins, Peter M. Grace   +3 more
doaj   +1 more source

Symptom screen: diagnostic usefulness in detecting pulmonary tuberculosis in HIV-infected pregnant women in Kenya [PDF]

, 2011
OBJECTIVE: To determine the diagnostic usefulness of tuberculosis (TB) symptom screening to detect active pulmonary TB among human immunodeficiency virus (HIV) infected pregnant women in two PMTCT (prevention of mother-to-child transmission) clinics in ...
Abuya, J M, Carter, E J, Edginton, M E, Fojo, T, Kosgei, R J, Mabeya, H, Mwangi, A, Ndavi, P M, Ong'ech, J O, Reid, T, Siika, A M, Wools-Kaloustian, K   +11 more
core   +2 more sources

Symptom lead time distribution in lung cancer:natural history and prospects for early diagnosis [PDF]

, 2014
BACKGROUND: Before their diagnosis, patients with cancer present in primary care more frequently than do matched controls. This has raised hopes that earlier investigation in primary care could lead to earlier stage at diagnosis.METHODS: We re-analysed ...
Ades, Anthony E., Biswas, Mousumi, Hamilton, William, Welton, Nicky J.   +3 more
core   +2 more sources

Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

Acta Neuropathologica Communications, 2018
Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs transfer mitochondria to neural stem cells (NSCs) to protect NSCs against ...
Nabila Boukelmoune, Gabriel S. Chiu, Annemieke Kavelaars, Cobi J. Heijnen   +3 more
doaj   +1 more source

CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior

Neurobiology of Pain, 2020
Background: Chronic pain and depression often co-occur. The mechanisms underlying this comorbidity are incompletely understood. Here, we investigated the role of CD3+ T cells in an inflammatory model of comorbid persistent mechanical allodynia ...
Geoffroy Laumet, Jules D. Edralin, Robert Dantzer, Cobi J. Heijnen, Annemieke Kavelaars   +4 more
doaj   +1 more source

Sensory neuron dysfunction in orthotopic mouse models of colon cancer

Journal of Neuroinflammation, 2022
Reports of neurological sequelae related to colon cancer are largely restricted to rare instances of paraneoplastic syndromes, due to autoimmune reactions.
Mihály Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd   +11 more
doaj   +1 more source

What's the Risk? Older Women Report Fewer Symptoms for Suspected Acute Coronary Syndrome than Younger Women. [PDF]

, 2018
The purpose of the study was to determine whether older (≥65 years) and younger (<65 years) women presenting to the emergency department (ED) with symptoms suggestive of acute coronary syndrome (ACS) varied on risk factors, comorbid conditions ...
Breen, Katherine, Burke, Larisa A, DeVon, Holli A, Mirzaei, Sahereh, Robinson, Nadia, Vuckovic, Karen, Zegre-Hemsey, Jessica   +6 more
core   +2 more sources

Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

Acta Neuropathologica Communications, 2022
Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities.
Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen   +9 more
doaj   +1 more source