Results 21 to 30 of about 1,244,853 (318)

Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

Acta Neuropathologica Communications, 2022
Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities.
Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen   +9 more
doaj   +1 more source

Symptoms and symptom presentation

Scandinavian Journal of Primary Health Care, 1992
In the theory of medicine, symptoms are logically related to defined bodily derangements. In the practice of medicine, doctors see patients who experience and present their symptoms in a personal way. With the twofold aim of investigating the clinical significance of this gap and of tracing a practice oriented diagnostic competence, a study was ...
openaire   +3 more sources

Symptoms of Diabetes

EDIS, 1969
Type 2 diabetes is a growing health concern for children as well as adults in the United States. Diabetes that is uncontrolled can lead to blindness, kidney disease, heart disease, and amputations. Early treatment to control blood glucose levels helps decrease a person’s chances of developing these health problems.
openaire   +13 more sources

Return of the symptom? [PDF]

Rheumatology, 2019
Identifying women and men at risk of fragility fractures, who can benefit from prevention strategies such as bisphosphonate therapy, is an important topic for clinical and population epidemiology.
Peter Croft, Zoe Paskins
openaire   +4 more sources

Impact of Virtual Reality Technology on Pain and Anxiety in Pediatric Burn Patients: A Systematic Review and Meta-Analysis

Frontiers in Virtual Reality, 2022
Introduction: Virtual reality (VR) has the potential to lessen pain and anxiety experienced by pediatric patients undergoing burn wound care procedures.
Kathryn L. Smith, Yang Wang, Yang Wang, Luana Colloca, Luana Colloca, Luana Colloca   +5 more
doaj   +1 more source

T Cells as an Emerging Target for Chronic Pain Therapy

Frontiers in Molecular Neuroscience, 2019
The immune system is critically involved in the development and maintenance of chronic pain. However, T cells, one of the main regulators of the immune response, have only recently become a focus of investigations on chronic pain pathophysiology ...
Geoffroy Laumet, Geoffroy Laumet, Jiacheng Ma, Alfred J. Robison, Susmita Kumari, Cobi J. Heijnen, Annemieke Kavelaars   +6 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Adverse childhood experiences and burn pain: a review of biopsychosocial mechanisms that may influence healing

PAIN Reports, 2022
. Adverse childhood experiences (ACEs) affect over half of the adults in the United States and are known to contribute to the development of a wide variety of negative health and behavioral outcomes.
Emily H. Werthman, Luana Colloca, Lynn M. Oswald   +2 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Telehealth virtual reality intervention reduces chronic pain in a randomized crossover study

npj Digital Medicine
The efficacy of telehealth Virtual Reality (VR) for chronic pain, a promising digital intervention, remains underexplored due to methodological challenges.
Luana Colloca, Anna Han, Rachel Massalee, Nandini Raghuraman, Rachel L. Cundiff-O’Sullivan, Giancarlo Colloca, Yang Wang   +6 more
doaj   +1 more source