Results 21 to 30 of about 3,788,125 (317)

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

Acta Neuropathologica Communications, 2020
Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in vitro ...
Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen   +5 more
doaj   +1 more source

Tracking macrophages in diabetic neuropathy with two-color nanoemulsions for near-infrared fluorescent imaging and microscopy

Journal of Neuroinflammation, 2021
Background The incidence of diabetes and diabetic peripheral neuropathy continues to rise, and studies have shown that macrophages play an important role in their pathogenesis.
James M. Nichols, Caitlin V. Crelli, Lu Liu, Hoang Vu Pham, Jelena M. Janjic, Andrew J. Shepherd   +5 more
doaj   +1 more source

Autoimmune regulation of chronic pain

PAIN Reports, 2021
. Chronic pain is an unpleasant and debilitating condition that is often poorly managed by existing therapeutics. Reciprocal interactions between the nervous system and the immune system have been recognized as playing an essential role in the initiation
Michael J. Lacagnina, Cobi J. Heijnen, Linda R. Watkins, Peter M. Grace   +3 more
doaj   +1 more source

Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app

Science Advances, 2020
Longitudinal clustering of symptoms can predict the need for respiratory support in severe COVID-19. As no one symptom can predict disease severity or the need for dedicated medical support in coronavirus disease 2019 (COVID-19), we asked whether ...
C. Sudre, KarlaA Lee, M. N. Lochlainn, Thomas Varsavsky, B. Murray, M. Graham, C. Menni, M. Modat, R. Bowyer, L. Nguyen, David A. Drew, A. Joshi, Wenjie Ma, Chuan-Guo Guo, Chun-Han Lo, S. Ganesh, A. Buwe, J. C. Pujol, J. Cadet, A. Visconti, M. Freidin, J. E. Moustafa, M. Falchi, R. Davies, M. Gomez, T. Fall, M. Cardoso, J. Wolf, P. Franks, A. Chan, T. Spector, C. Steves, S. Ourselin, S. Ourselin   +33 more
semanticscholar   +1 more source

Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

Acta Neuropathologica Communications, 2018
Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs transfer mitochondria to neural stem cells (NSCs) to protect NSCs against ...
Nabila Boukelmoune, Gabriel S. Chiu, Annemieke Kavelaars, Cobi J. Heijnen   +3 more
doaj   +1 more source

CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior

Neurobiology of Pain, 2020
Background: Chronic pain and depression often co-occur. The mechanisms underlying this comorbidity are incompletely understood. Here, we investigated the role of CD3+ T cells in an inflammatory model of comorbid persistent mechanical allodynia ...
Geoffroy Laumet, Jules D. Edralin, Robert Dantzer, Cobi J. Heijnen, Annemieke Kavelaars   +4 more
doaj   +1 more source

Sensory neuron dysfunction in orthotopic mouse models of colon cancer

Journal of Neuroinflammation, 2022
Reports of neurological sequelae related to colon cancer are largely restricted to rare instances of paraneoplastic syndromes, due to autoimmune reactions.
Mihály Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd   +11 more
doaj   +1 more source

Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

Acta Neuropathologica Communications, 2022
Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities.
Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen   +9 more
doaj   +1 more source

Symptoms and symptom presentation

Scandinavian Journal of Primary Health Care, 1992
In the theory of medicine, symptoms are logically related to defined bodily derangements. In the practice of medicine, doctors see patients who experience and present their symptoms in a personal way. With the twofold aim of investigating the clinical significance of this gap and of tracing a practice oriented diagnostic competence, a study was ...
openaire   +2 more sources

Distinct Symptom-Specific Treatment Targets for Circuit-Based Neuromodulation.

American Journal of Psychiatry, 2019
OBJECTIVE Treatment of different depression symptoms may require different brain stimulation targets with different underlying brain circuits. The authors sought to identify such targets, which could improve the efficacy of therapeutic brain stimulation ...
S. Siddiqi, S. Taylor, D. Cooke, Á. Pascual-Leone, M. George, M. Fox   +5 more
semanticscholar   +1 more source