Results 61 to 70 of about 1,397,203 (301)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Deciphering transcriptomic changes in chemobrain: a comprehensive review

Acta Neuropathologica Communications
Chemotherapy-induced cognitive impairments (CICI), colloquially known as “chemobrain,” represents a profound and debilitating side effect experienced by a significant number of cancer survivors, impacting their memory, multitasking, and quality of life ...
Tusar Kanta Acharya, Yuan Pan, Peter M. Grace, Cobi J. Heijnen, Rajasekaran Mahalingam   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assessing the representativeness of large medical data using population stability index

BMC Medical Research Methodology
Background Understanding sample representativeness is key to interpreting findings from epidemiological research and applying these findings to broader populations.
Sheng-Chieh Lu, Wenye Song, Andre Pfob, Chris Gibbons   +3 more
doaj   +1 more source

Symptoms? Which Symptoms? Distorted Symptom Presentation and Its Detection

In this chapter, we elaborated on the two main forms of distorted symptom reporting: symptom over- and underreporting. In certain situations, individuals might exaggerate their symptoms. For instance, defendants facing legal issues may overstate their mental health problems.
Merckelbach, Harald, Boškovic, Irena
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Cobaltism-Symptom-Inventory (CSI).

, 2023
IntroductionCobalt is a mitochondrial toxin, clinical cobaltism manifests with constitutional, neurologic, and cardiovascular symptomatology. Cobalt’s severe toxidrome is known through case reports from extreme wear or corrosion of cobalt-chromium ...
Christina S. Cho (17691680), Bradford D. Gessner (7527548), Stephen S. Tower (17691677), Robert L. Bridges (17691683)   +3 more
core   +1 more source

Role of patient-reported outcomes in geriatric oncology research and patient care

Holistic Integrative Oncology
Health-related quality of life (HRQOL) and daily functioning are central considerations for older adults with cancer. Attention to symptom burden, daily functioning, and HRQOL is imperative in this patient population to identify relevant research ...
Xin Shelley Wang, Charles S. Cleeland
doaj   +1 more source

Evaluation of the psychometric properties and minimally important difference of the MD Anderson Symptom Inventory for malignant pleural mesothelioma (MDASI-MPM)

Journal of Patient-Reported Outcomes, 2019
Background Symptom assessment requires psychometrically validated questionnaires that are easy to use, relevant to the disease, and quick to administer. The MD Anderson Symptom Inventory for malignant pleural mesothelioma (MDASI-MPM) was adapted from the
Tito R. Mendoza, Loretta A. Williams, Karen N. Keating, Jonathan Siegel, Cem Elbi, Anna K. Nowak, Raffit Hassan, Brian Cuffel, Charles S. Cleeland   +8 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source