Results 121 to 130 of about 948,446 (317)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Young infants with symptomatic tetralogy of Fallot: Shunt or primary repair?Central MessagePerspective

JTCVS Open
Objectives: The optimal treatment strategy for symptomatic young infants with tetralogy of Fallot (TOF) is unclear. We sought to compare the outcomes of staged repair (SR) (shunt palliation followed by second-stage complete repair) versus primary repair (
Xin Tao Ye, MD, Soichiro Henmi, MD, PhD, Edward Buratto, MBBS, PhD, Mitchell C. Haverty, MS, Can Yerebakan, MD, Tyson Fricke, MBBS, PhD, Christian P. Brizard, MD, MS, Yves d’Udekem, MD, PhD, Igor E. Konstantinov, MD, PhD   +8 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Post-Theory and Beyond

Revista Brasileira de Literatura Comparada
This article surveys and assesses the eclectic trends in literary theory and criticism in the posttheory age with a focus on three rubrics: the cultural turn, the historic turn, and the affective turn.
Luiz Fernando Valente
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Symptomatic Narcolepsies [PDF]

Sleep, 1994
A, Autret, B, Lucas, F, Henry-Lebras, B, de Toffol   +3 more
openaire   +2 more sources

Mansonella perstans causing symptomatic hypereosinophilia in a missionary family

, 2006
Mansonella perstans is rarely pathogenic. The rare reports of symptomatic cases, however, include severe complications. Three cases of symptomatic hypereosinophilia with multi-organ involvement are described in a missionary family returning from tropical
Fux, Christoph A, Aebi, Christoph, Marti, Hanspeter, Hatz, Christoph, Holzer, Benedikt, Chappuis, Bernard, Bordmann, Gerard   +6 more
core  

Comparison of serum antibody responses to Giardia lamblia of symptomatic and asymptomatic patients

, 1998
The circulating anti-parasite antibody response against Giardia lamblia in symptomatic and asymptomatic Egyptian children with confirmed giardiasis was examined.
Abou-Shady, A.F., Belosevic, M., El-Mageid, S.A., Handousa, A.A., Hegazi, M.M., Taghi-Kilani, R., Soliman, M.M.   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source