Results 141 to 150 of about 948,446 (317)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Study of Macular Microvascular Changes in Patients with Symptomatic Lacunar Cerebral Infarction Using Viaoptical Coherence Tomography Angiography (OCTA) [PDF]

Meishuang Li,1– 4,* Huiyu Xi,1,3,4,* Rongrong Guan,5,* Yalu Liu,1,3,4 Lina Guan,1,3,4 Dandan Zong,1,4,6 Nuan Wang,1,4 Haiyang Liu1,3,4 1Department of Ophthalmology, Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University,
Xi H, Liu H, Liu Y, Guan L, Zong D, Wang N, Guan R, Li M   +7 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Symptomatic Treatment [PDF]

Postgraduate Medical Journal, 1943
openaire   +2 more sources

An epidemiologic study on symptomatic pelvic organ prolapse in obese Chinese women: a population-based study in China

, 2018
Zhiyi Li,1 Tao Xu,2 Zhaoai Li,3 Jian Gong,4 Qing Liu,5 Yulin Wang,6 Juntao Wang,7 Zhijun Xia,8 Lan Zhu1 1Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences ...
Li Z, Xia Z, Zhu L, Xu T, Liu Q, Gong J, Wang Y, Wang J   +7 more
core  

Symptomatic networks in suicide attempt and reattempt: Relevance of psychiatric comorbidity

Background. One of the most relevant risk factors for suicide is the presence of previous attempts. The symptomatic profile of people who reattempt suicide deserves attention. Network analysis is a promising tool to study this field. Objective.
Torre-Luque, Alejandro de la, Pemau, Andrés, Ayad-Ahmed, Wala, Ruiz Veguilla, Miguel, Marín-Martin, Carolina, Diaz-Marsa, M, Crespo Facorro, Benedicto, Pérez, Víctor, Andreo-Jover, Jorge   +8 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

SYMPTOMATIC EPIPHORA [PDF]

British Journal of Ophthalmology, 1959
openaire   +2 more sources

Symptomatic Splenoma in a Child [PDF]

Annals of Saudi Medicine, 2009
Shah Parveen, Robbani Irfan, Khan Athar, Shah Omar   +3 more
openaire   +2 more sources