Results 91 to 100 of about 2,054,384 (304)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Associations of severe hyperlactataemia and lactic acidosis in HIV-infected patients receiving antiretroviral theraphy [PDF]

, 2007
Includes bibliographical references (leaves 67-70).Severe symptomatic hyperlactataemia and lactic acidosis (SHLA) are life-threatening events that are occurring at increasing incidence levels in South Africa.
Osler, Meg
core  

A Novel Case of Symptomatic BK Viraemia in a Patient Undergoing Treatment for Hodgkin Lymphoma [PDF]

, 2014
Symptomatic BK viral infection in the immunocompromised host is well described, most commonly seen in renal transplant recipients, bone marrow transplant recipients, and HIV positive patients.
Jacinta Perram, Jane Estell
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Placental histopathology after Coxiella burnetii infection during pregnancy [PDF]

, 2012
Symptomatic and asymptomatic Coxiella burnetii infection during pregnancy have been associated with obstetric complications. We described placental histopathology and clinical outcome of five cases with asymptomatic C. burnetii infection during pregnancy
Timmer, A., Hamilton, C. J. C. M., A.C.A.P. Leenders, J.G. Aarnoudse, E. Hak, Hak, E., Leenders, A. C. A. P., Aarnoudse, J. G., A. Timmer, J.M. Munster, Munster, J. M., C.J.C.M. Hamilton   +11 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A case of neonatal cytomegalovirus infection with severe thrombocytopenia that was successfully managed with empiric antiviral therapy

IDCases, 2020
Antiviral therapy against cytomegalovirus (CMV) infection is indicated for symptomatic infection in the fetus and premature neonates. In mature neonates, the benefit of antiviral therapy for severe CMV infection remains controversial.
Kentaro Fujimori, Masaki Yamada, Takanobu Maekawa, Nobuyuki Yotani, Ei-ichiro Tamura, Ken-ichi Imadome, Mitsuru Kubota, Akira Ishiguro   +7 more
doaj   +1 more source

A study on the cell mediated immunity of human cytomegalovirus infection in kidney transplant recipients [PDF]

Cytomegalovirus (CMV) infection is a major complication after kidney transplantation. Despite antiviral therapy it contributes significantly to high morbidity. This study was aimed at (a) detecting· a CMV specific antigen pp65 in CMV -infected fibroblast
Essa, Sahar Sultan
core  

Individuals with Le(a+b−) Blood Group have Increased Susceptibility to Symptomatic \(Vibrio\) \(cholerae\) O1 Infection [PDF]

, 2011
Background: Human genetic factors such as blood group antigens may affect the severity of infectious diseases. Presence of specific ABO and Lewis blood group antigens has been shown previously to be associated with the risk of different enteric ...
Mohammad Arifuzzaman, Calderwood, Stephen, Rahman Mohammad Arif, Qadri Firdausi, Bhuiyan Taufiqur Rahman, Qadri, Firdausi, Tanvir Ahmed, Larocque, Regina, Khan, Ashraful I., Arifuzzaman, Mohammad, Rashu Rasheduzzaman, Jason B Harris, Stephen B Calderwood, Calderwood Stephen B., Harris, Jason, Regina C LaRocque, Taufiqur Rahman Bhuiyan, Chowdhury, Fahima, LaRocque Regina C., Rashu, Rasheduzzaman, Harris Jason B., Firdausi Qadri, Rahman, Mohammad Arif, Edward T Ryan, Fahima Chowdhury, Ryan, Edward, Khan Ashraful I., Chowdhury Fahima, Ryan Edward T., Rasheduzzaman Rashu, Ahmed, Tanvir, Ashraful I Khan, Bhuiyan, Taufiqur Rahman, Arifuzzaman Mohammad, Ahmed Tanvir, Mohammad Arif Rahman   +35 more
core   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source