Results 101 to 110 of about 2,054,384 (304)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Symptomatic HIV infection in infancy--clinical and laboratory markers of infection.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1997
To investigate the usefulness of immunological tests in the diagnosis of HIV infection in young symptomatic children (< 15 months of age).Tests were evaluated in HIV-infected (HIV antibody- and PCR-positive) patients and non-infected individuals.Hospitalised patients in a referral centre (Red Cross War Memorial Children's Hospital, Cape Town).All ...
Meyer, M.P., Latief, Z, Haworth, C, Salie, S, van Dyk, A   +4 more
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

CONGENITAL CMV INFECTION; DIAGNOSIS IN SYMPTOMATIC INFANTS

Indian Journal of Medical Microbiology, 2009
Samples from babies exhibiting clinical symptoms suggestive of congenital infection are referred regularly to NICD, New Delhi,, from Government Hospitals located in Delhi and a home for abandoned children (Palna), for the diagnosis of etiological agents like toxoplasma, rubella, CMV and herpes.
Gandhoke, I, Aggarwal, R, Hussain, SA, Pasha, ST, Sethi, P, Thakur, S, Lal, S, Khare, S   +7 more
openaire   +2 more sources

Changing concepts of "latent tuberculosis infection" in patients living with HIV infection. [PDF]

, 2011
One third of the world's population is estimated to be infected with Mycobacterium tuberculosis, representing a huge reservoir of potential tuberculosis (TB) disease. Risk of progression to active TB is highest in those with HIV coinfection. However, the
Robert J. Wilkinson, Wood, R, Lawn, Stephen D, Wilkinson, RJ, Robin Wood, Lawn, SD, Wood, Robin, Wilkinson, Robert J, Stephen D. Lawn   +8 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Characteristics of Mild Dengue Virus Infection in Thai Children [PDF]

, 2013
A four-year longitudinal cohort and geographic cluster study in rural Thailand was conducted to characterize the clinical spectrum of dengue virus (DENV) infection.
Srikiatkhachorn, Anon, Alan L. Rothman, Green, Sharone, Hermann, Laura, Aldstadt, Jared, Thammapalo, Suwich, Scott, Thomas W, Mammen P. Mammen, Anon Srikiatkhachorn, Gibbons, Robert V., Laura Hermann, Piraya Bhoomiboonchoo, Jared Aldstadt, Buddhari, Darunee, Bhoomiboonchoo, Piraya, Scott, Thomas W., In-Kyu Yoon, Rothman, Alan L, Suwich Thammapalo, Robert V. Gibbons, Jarman, Richard G, Gibbons, Robert V, Darunee Buddhari, Endy, Timothy P., Endy, Timothy P, Thomas W. Scott, Jarman, Richard G., Ananda Nisalak, Richard G. Jarman, Rothman, Alan L., Nisalak, Ananda, Yoon, In-Kyu, Mammen, Mammen P, Mammen, Mammen P., Sharone Green, Timothy P. Endy   +35 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Use of electronic health records to investigate the role of acute inflammation and infection in vascular disease [PDF]

Previous studies have demonstrated that acute systemic inflammation after surgery or infection is associated with a transient increase in the risk of vascular events. This suggests that vascular risk is not stable but fluctuates within short periods in
Minassian, C
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source