Results 121 to 130 of about 2,054,384 (304)

Progression of the proportion of dogs with symptomatic infection as assessed by a survival curve analysis.

, 2014
The status of the dogs was assessed at months 9, 15, 18, 21 and 24 using the classification system in figure 1. Symptomatic infection was identified by positive PCR and positive culture associated with a clinical score>3.
Javier Moreno (131401), Sylvie Gueguen (318821), Valentina Foglia Manzillo (411537), Gaetano Oliva (411545), Aldo Scalone (411540), Luigi Gradoni (361885), Virginie Martin (318817), Therese Butaud (641747), Javier Nieto (131402), Eleonora Fiorentino (411542), Trentina Di Muccio (411538), Carmen Cañavate (50529), Silvia Cappiello (641746), Carmen Chicharro (50528), Laurie Guegand (641748), David McGahie (318818), Eugenia Carrillo (527016), Anne-Marie Cuisinier (318819)   +17 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Symptomatic primary HIV infection in a 49-year-old man who has sex with men: beware of the window phase [PDF]

, 2009
A 49-year-old man with a history of receptive unprotected anal intercourse with multiple anonymous men presented with a symptomatic primary HIV infection.
M Damen, H E van Oosten, de Vries, H.J.C., van Oosten, H.E., Damen, M., H JC de Vries   +5 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Influenza virus prevalence in asymptomatic and symptomatic subjects during pandemic and postpandemic periods

, 2015
Background: in 2009, Influenza A(H1N1) pdm09 had a major effect on global health, causing thousands of deaths. However, the results of asymptomatic infection in transmission has not been well studied.
Melchior, Thaís Boim [UNIFESP], Granato, Celso [UNIFESP], Bellei, Nancy [UNIFESP], Perosa, Ana Helena [UNIFESP], Camargo, Clarice Neves [UNIFESP]   +4 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

FREQUENCY OF INFECTED BILE IN PATIENTS OF UNCOMPLICATED GALLSTONE DISEASE

Pakistan Armed Forces Medical Journal, 2010
Objective: To find out the association of bile infection with uncomplicated gallstone disease in our setup. Study Design: A Case control study. Place and duration of study: This study was carried out at Surgical Department Combined Military Hospital ...
Maj Nasir Mahmud Wattoo
doaj   +2 more sources

MIF is a common genetic determinant of COVID-19 symptomatic infection and severity. [PDF]

QJM, 2023
Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Baeza Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Ocskay K, Garcia-Blesa A, Hegyi P, Armstrong ME, Mitchell PD, Bernardo D, Garami A, Kang I, Bucala R.   +29 more
europepmc   +1 more source