Results 151 to 160 of about 175,000 (211)

Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α‑Synuclein Phase Separation. [PDF]

JACS Au
Yang Z, Tang Y, Wen J, Guo C, Zhou Y, Wang Z, Pan T, Tan Y, Perrett S, Wu S, Wei G.   +10 more
europepmc   +1 more source

Apatite in Carbonatite Preserving Primary Magmatic, Post‐Magmatic Overgrowth, and Post India‐Asia Collision‐Related Hydrothermal Alteration: Evidenced From U–Pb Isotope and Trace Element Geochemistry

Geological Journal, EarlyView.
U–Pb isotope and trace element geochemistry of apatite from carbonatites of Peshawar Plain Alkaline Igneous Province, western Himalaya shows Permo‐Carboniferous magmatism, an additional magmatic pulse during Cretaceous, and post‐magmatic hydrothermal/metasomatism during Oligocene. ABSTRACT U–Pb isotope and trace element geochemistry of apatite combined
Mehboob ur Rashid, Hafiz U. Rehman, Hao‐Yang Lee, Sun‐Lin Chung, Kaushik Das, Kazumasa Aoki, Muhammad Jawad Zeb, Nasir Ahmad, Muhammad Hussain, Hiroshi Yamamoto   +9 more
wiley   +1 more source

Heterogeneous Exhumation Mechanisms in Neoproterozoic Collisional Metamorphism: P–T Constraints From Pelotas and Punta del Este Terranes, Southern Brazil and Uruguay

Geological Journal, EarlyView.
Petrography, thermobarometry, and pseudosection modelling reveal peak metamorphic conditions of 3–7.5 kbar and 520°C–800°C in Tonian‐Cryogenian orthogneisses of the Dom Feliciano Belt. Metamorphic field gradients of 27°C/km–39°C/km and variable exhumation mechanisms support correlation of these units as remnants of a Himalayan‐type Piratini Orogeny ...
Thaiane Niederauer‐Santos, Carla Cristine Porcher, Daniel Triboli Vieira, Edinei Koester, Diego Jaldín, Karina Luengo, Luisa Caon   +6 more
wiley   +1 more source

Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains. [PDF]

Cell Stem Cell
Mesentier-Louro LA, Goldman C, Gaese S, Buonfiglioli A, Kyriakis D, Harlock A, Ndayisaba A, Sartori ER, Uchitelev A, Fullard JF, Hennigan E, Lee D, Schuldt BR, Rooklin RB, Barra J, Bravo-Cordero JJ, Roussos P, Khurana V, Blanchard JW.   +18 more
europepmc   +1 more source

In vivo detection of pathologic α- synuclein and TDP-43 in the skin and olfactory mucosa of a patient with Parkinson's disease-like phenotype carrying the p.Thr272Serfs*10 GRN mutation. [PDF]

Mol Neurodegener
Caroppo P, Aprea V, Villa C, Dellarole IL, Romeo A, Rossi G, Ciullini A, Burato A, Prioni S, Grisoli M, Legname G, Simmini G, Luppino A, Mazzetti S, Moda F, Devigili G.   +15 more
europepmc   +1 more source

Miocene to Quaternary Tectonostratigraphic Evolution of the Northern Section of the Burdur‐Fethiye Shear Zone, South‐Western Türkiye

Geological Journal, EarlyView.
New zircon ages reveal that lacustrine sedimentation initiated in the Late Miocene (Messinian), revising earlier Pliocene age assignments. The study results support the interpretation of the northern BFSZ as a broad left‐lateral transtensional shear zone rather than a discrete sinistral fault or simple extensional graben array.
İrem Elitez, Gürsel Sunal, Cenk Yaltırak, İsak Yılmaz   +3 more
wiley   +1 more source

Convergent Astrocytic Failure in Parkinson's Disease: A System-Level Model of Pathogenesis and Treatment. [PDF]

Mol Neurobiol
Abdelaziz AM, Fawzy MN, Shokr MM.
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source