UV Laser‐Induced Carbon Microelectrode Arrays for Neuronal Recordings
Thin‐film electrodes are flexible devices of high conformability and minimal dimensions with attractive properties for in vivo and in vitro bioelectronics. Here, electrodes are developed from parylene films via ultraviolet laser‐induced carbonization.
Fulvia Del Duca+10 more
wiley +1 more source
Contribution of individual excitatory synapses on dendritic spines to electrical signaling
Dendritic spines, ∼1 μm protrusions from neuronal dendrites that receive most of the excitatory synaptic inputs in the mammalian brain, are widely considered the elementary computational units in the nervous system.
Ju-Yun Weng+2 more
doaj +1 more source
Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma
A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li+8 more
wiley +1 more source
The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI
BackgroundTraumatic brain injury (TBI) induces an acute reactive state of microglia, which contribute to secondary injury processes through phagocytic activity and release of cytokines.
Rida Rehman+11 more
doaj +1 more source
The Marr and Albus Theories of the Cerebellum: Two Eary Models of Associative Memory [PDF]
The Marr and Albus theories of the cerebellum are compared and contrasted. They are shown to be similar in their analysis of the function of the mossy fibers, granule cells, Golgi cells, and Purkinje cells.
Albus, James S.
core +1 more source
TraNNsformer: Neural network transformation for memristive crossbar based neuromorphic system design
Implementation of Neuromorphic Systems using post Complementary Metal-Oxide-Semiconductor (CMOS) technology based Memristive Crossbar Array (MCA) has emerged as a promising solution to enable low-power acceleration of neural networks. However, the recent
Ankit, Aayush+2 more
core +1 more source
AI‐Assisted Design and Evaluation of SLM‐Ti64 Implants for Enhanced Bone Regeneration
AI‐driven simulations of biological healing, combining biomechanical modeling and machine learning, enable personalized orthopedic treatments. By decoding healing patterns influenced by implants and patient‐specific factors, this approach advances fracture repair understanding, optimizes implant design, and supports precision medicine and sustainable ...
Muhammad Usama Zaheer+3 more
wiley +1 more source
Objective To investigate the effects of adenovirus-associated virus (AAV)-mediated overexpression of LINGO-1 in the hippocampus on spatial learning and memory abilities, as well as the volume and Spinophilin+ dendritic spines of different subregions ...
WANG Shun, JIANG Lin, HE Qi
doaj +1 more source
Organic core-sheath nanowire artificial synapses with femtojoule energy consumption
Researchers report an organic nanowire artificial synapse that emulates working principles and energy consumption of biological synapses. Emulation of biological synapses is an important step toward construction of large-scale brain-inspired electronics.
Wentao Xu+3 more
semanticscholar +1 more source
Synapses: Glia help synapses form and function [PDF]
AbstractA sophisticated new cell-culture system has shown that glial cells can promote synaptogenesis and enhance the efficacy of synaptic transmission. These effects are not secondary to increased neuronal survival but probably involve changes in neuronal activity levels and a secreted glial factor.
openaire +2 more sources