Results 211 to 220 of about 460,902 (390)

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

Modeling presynaptic inhibition by the amyloid precursor protein demonstrates one potential mechanism for preventing runaway synaptic modification in Alzheimer's disease. [PDF]

Alzheimers Dement
Barber D, Hasselmo ME, Rice HC.
europepmc   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source

Chemical Pharmacology of the Synapse [PDF]

, 1977
J. S. Gillespie
openalex   +1 more source

Phase‐Change Materials for Volatile Threshold Resistive Switching and Neuronal Device Applications

Advanced Science, EarlyView.
Volatile threshold switching materials are an important pathway to simulate neuronal behavior. This review summarizes recent advances in the development of volatile resistive switching devices and neuronal oscillators based on three representative phase change materials, emphasizes the major challenges in this rapidly evolving field, and provides an ...
Huandong Chen, Jayakanth Ravichandran
wiley   +1 more source

Osnovi glutamatergičke neurotransmisije [PDF]

Vojnosanitetski Pregled, 2004
Milovanović Dragan R., Janković Slobodan M.   +1 more
doaj   +1 more source

Synaptic pruning following NMDAR-dependent LTD preferentially affects isolated synapses. [PDF]

iScience
Camus C, Leval L, Villicana-Munoz V, Jelinkova S, Compans B, Gambino F, Herzog E, Choquet D, Hosy E.   +8 more
europepmc   +1 more source

Calcium role in depolarization-secretion coupling: an aequorin study in squid giant synapse. [PDF]

, 1975
R. Llinás, Charles Nicholson
openalex   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Synaptic imbalance and increased inhibition impair motor function in SMA. [PDF]

Sci Adv
Fletcher EV, Chalif JI, Rotterman TM, Pagiazitis JG, Van Alstyne M, Sivakumar N, Florez-Paz D, Rabinowitz JE, Pellizzoni L, Alvarez FJ, Mentis GZ.   +10 more
europepmc   +1 more source