Results 191 to 200 of about 328,871 (251)

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Oligodendrocyte Precursor Cells Shape Retinogeniculate Refinement Via a CHD8-Dependent Phagocytic Pathway. [PDF]

Invest Ophthalmol Vis Sci
Wen S, Guo F, Li Z, Huang G, Shen M, He X.   +5 more
europepmc   +1 more source

Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients

Clinical Pharmacology &Therapeutics, EarlyView.
ISB 2001 is a trispecific antibody that binds to two tumor‐associated antigens (TAA), CD38 and BCMA, and crosslinks to CD3 on T cells resulting in T cell‐mediated cytotoxicity of tumor cells expressing these TAAs. ISB 2001 is currently being tested in relapsed and/or refractory multiple myeloma (RRMM) patients in the first‐in‐human (FIH) TRIgnite‐1 ...
Vinu Chandralayam Ayyappa Menon, Tomomi Matsuura, Beata Holkova, Girish S. Gudi, Adam Drake, Maria Pihlgren, Piet H. van der Graaf, Sunitha GN, Andrew Garton, Mario Perro, Cyril Konto, Lida Pacaud   +11 more
wiley   +1 more source

Identification of T:B Cell Multimers After Bispecific T Cell Engagement, Using Both Conventional and Imaging Flow Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Bispecific T cell engagers bring together T cells with malignant B cell targets to enable synapse formation and disease eradication of hematological malignancies. The proportion of T cells and their ability to bind to their targets varies between patients and may be a biomarker of response.
Joanne E. Davis, Mandy Ludford‐Menting, Helena Peng, Darryl N. Johnson, David S. Ritchie, Rachel Koldej   +5 more
wiley   +1 more source

Extracellular space diffusion modelling identifies distinct functional advantages of glutamatergic and GABAergic synapse geometries. [PDF]

Fluids Barriers CNS
Gimenez P, Shakya RT, Santamaria F, Tønnesen J.   +3 more
europepmc   +1 more source

Glutamate Delta 1 Receptor in Synapses, Circuits, and Disease. [PDF]

Eur J Neurosci
Choi D, Chettiar PB, Smith Y, Dravid SM.
europepmc   +1 more source

Orchestrating synaptic strength by neuroligin-confined nanoscale organization. [PDF]

Mol Cells
Han Y, Dai X, Zhang B.
europepmc   +1 more source

Biomimetic Synapses Based on Halide Perovskites for Neuromorphic Vision Computing: Materials, Devices, and Applications. [PDF]

Nanomicro Lett
Sun Z, Zhao X, Si H, Liao Q, Zhang Y.
europepmc   +1 more source

AMPA Receptors in NG2 Glia Differently Affect Signal Transduction in the Hippocampus and Cerebellum. [PDF]

Glia
Tascio D, Gebril N, Jabs R, Henneberger C, Steinhäuser C, Seifert G.   +5 more
europepmc   +1 more source