Results 91 to 100 of about 1,301 (201)
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
A defect in synapsis causes male sterility in a T‐DNA‐tagged Arabidopsis thaliana mutant [PDF]
, 1997 Brenda N. Peirson +2 more
openalex +1 more source
Advanced Science, EarlyView.By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini +24 more
wiley +1 more source
Meiotic Prophase Arrest with Failure of Chromosome Synapsis in Mice Deficient for Dmc1 , a Germline-Specific RecA Homolog [PDF]
, 1998 Douglas L. Pittman +7 more
openalex +1 more source
Advanced Science, EarlyView.Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae +9 more
wiley +1 more source
Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage [PDF]
, 1997 Quinn Eastman, David G. Schatz
openalex +1 more source
Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction
Advanced Science, EarlyView.This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong +11 more
wiley +1 more source
Advanced Science, EarlyView.This study examines the effects of Shank3 mutation on the mesoaccumbens pathway using a Shank3‐deficient rat model. The findings reveal altered social reward processing in these rats, accompanied by changes in dopaminergic and GABAergic neural activity within the ventral tegmental area (VTA) and dopamine release in the nucleus accumbense (NAc ...
Marie Barbier +4 more
wiley +1 more source
The Mouse Spo11 Gene Is Required for Meiotic Chromosome Synapsis [PDF]
, 2000 Peter Romanienko +1 more
openalex +1 more source
Advanced Science, EarlyView.Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou +9 more
wiley +1 more source