Results 181 to 190 of about 26,734 (323)
Advanced Science, EarlyView.This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li +11 more
wiley +1 more source
Chromosome pairing in altered constitutions and models of synapsis and crossing-over [PDF]
, 1968 Marjorie P. Maguire
openalex +1 more source
Advanced Science, EarlyView.Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong +19 more
wiley +1 more source
Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly
Nature Structural & Molecular Biology, 2018 J. M. Dunce +6 more
semanticscholar +1 more source
Update Disturbance‐Resilient Analog ReRAM Crossbar Arrays for In‐Memory Deep Learning Accelerators
Advanced Science, EarlyView.Conductive metal oxide/HfOx analog ReRAM on 350 nm technology is presented for in‐memory deep learning accelerators. The device exhibits analog and nonvolatile conductance switching and high resilience to update disturbances, which is supported by COMSOL Multiphysics simulations.
Wooseok Choi +16 more
wiley +1 more source
SUMO Localizes to the Central Element of the Synaptonemal Complex and is Essential for Meiotic Chromosome Synapsis in Saccharomyces cerevisiae [PDF]
, 2013 Louis F. Taylor
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Advanced Science, EarlyView.MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer +18 more
wiley +1 more source
Synaptonemal Complex-Dependent Centromeric Clustering and the Initiation of Synapsis in Drosophila Oocytes [PDF]
, 2011 Satomi Takeo +4 more
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Advanced Science, EarlyView.In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source