Results 211 to 220 of about 23,521 (333)

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, EarlyView.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source

Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish. [PDF]

PLoS Genet
Olaya I, Yilmaz IN, Nour-Kasally N, Charboneau RE, Draper BW, Burgess SM.   +5 more
europepmc   +1 more source

SCC3 is an axial element essential for homologous chromosome pairing and synapsis

Yangzi Zhao, Lijun Ren, Tingting Zhao, Hanli You, Yongjie Miao, Huixin Liu, Lei Cao, Bingxin Wang, Yi Shen, Yafei Li, Ding Tang, Zhukuan Cheng   +11 more
openalex   +1 more source

Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3

, 2023
James H. Crichton, James M. Dunce, Orla M. Dunne, Lucy J. Salmon, Paul S. Devenney, Jennifer Lawson, Ian R. Adams, Owen R. Davies   +7 more
openalex   +2 more sources

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Chromatin remodeler ISW-1 orchestrates chromosome axis assembly and meiotic progression in C. elegans. [PDF]

Nucleic Acids Res
Wang R, Sun Y, Kang J, Tian J, Wang S, Zhu Z, Zhao L, Qi F, Gao J.   +8 more
europepmc   +1 more source

Telomere distribution pattern and synapsis initiation during spermatogenesis in zebrafish [PDF]

, 2014
Kenji Saito, Chiharu Sakai, Toshihiroa Kawasaki, Noriyoshi Sakai   +3 more
openalex   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Synapsis and meiotic recombination analyses: MLH1 focus in the XY pair as an indicator [PDF]

, 2005
M. Codina‐Pascual, M. Oliver‐Bonet, J. Navarro, Mercedes Campillo, Ferrán García, Susana Egozcue, Carlos Abad, Josep Egozcue, J. Benet   +8 more
openalex   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source